1.B.2.1.2
Major outer membrance protein MomP (OmpA, Omp1, Omp1L2) of 394 aas; 1 N-terminal TMS Rodríguez-Marañón et al., 2002). This protein is covalently linked to two other cys-rich proteins via disulfide bonds, OmcA (Omp2A; Omp3) with 88 aas and 1 N-terminal TMS, and OmcB (Omp2, Omp2B) with 547 aas and 1 N-terminal TMS. Together these proteins comprise the Chlamydial outer membrane complex (COMC) (Findlay et al. 2005). MOMP is the most suitable substitute for whole cell targets for vaccine production, and its delivery as a combined systemic and mucosal vaccine is most effective (Phillips et al. 2019). It is also a drug target (Sadhasivam et al. 2019).  The efficacy of a novel affitoxin targeting MOMP against Chlamydia trachomatis in vitro and in vivo has been reported (Li et al. 2024).