8.B.21.1.11
γ-conotoxin PiVIIA of 25 aas. Micromolar concentrations of PiVIIA increased the magnitude of the
macroscopic calcium current in DRG neurons from rats. An increase, even
modest of the calcium current, may have a significant impact on the
excitability and electrical activity of neurons, and may set up PiVIIA
as a member of the pharmacological family of the gamma-conotoxins (Bernáldez et al. 2016).
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| Accession Number: | P0DUW6 |
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| Protein Name: | Toxin CcTX-1 |
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| Length: | 243 |
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| Molecular Weight: | 27654.00 |
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| Species: | Cyanea capillata (Lion's mane jellyfish) [27804] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
|
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1: SSPEKKNDMS KPGRMRFDNK KEPRSSAKNS GNGYGCVDVN AGREPLTGPG KYPSSFLLLL
61: EHRKPPDKDR DRWDNVKGCE RKDGKSHWYD SMLKHRSPRE KTLVGSGKDS TNFVYRLLTE
121: PLLNERAGCK VVDMWYSLSY WMDVVNKRFG LCHYLGSMMD HGRWNDYSLC KDSYAGKHKP
181: AGGPPTPRLK NREECKFYWC WSGSEERAGG MGREYVMHSG GLYGDLTDKR DDPEPNGNLE
241: GGV