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3.D.4.11.1
Cytochrome oxidase (Cox or CcO).  Reversible hydration-level changes of the cavity can be a key factor that regulates the branching of proton transfer events and therefore contributes to the vectorial efficiency of proton transport (Son et al. 2017). Cox16 is required for the assembly of the mitochondrial cytochrome c oxidase (respiratory chain complex IV (CIV)), possibly by promoting the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (Cerqua et al. 2018; Aich et al. 2018). Lipid composition affects the efficiency of the functional reconstitution of the cytochrome c oxidase (Hugentobler et al. 2020). The DeepCys program has been used to predict the functions of cysteine residues in Cox2 (Nallapareddy et al. 2021).

Accession Number:P10606
Protein Name:CoxVb
Length:129
Molecular Weight:13696.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate hydron

Cross database links:

RefSeq: NP_001853.2   
Entrez Gene ID: 1329   
Pfam: PF01215   
OMIM: 123866  gene
KEGG: hsa:1329   

Gene Ontology

GO:0005743 C:mitochondrial inner membrane
GO:0004129 F:cytochrome-c oxidase activity
GO:0046872 F:metal ion binding
GO:0007585 P:respiratory gaseous exchange

References (6)

[1] “Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase.”  Zeviani M.et.al.   2840351
[2] “Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes.”  Lomax M.I.et.al.   1646156
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter.”  Bachman N.J.et.al.   8806766
[5] “Human liver protein map: update 1993.”  Hughes G.J.et.al.   8313870
[6] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
Structure:
5Z62     

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FASTA formatted sequence 
1:	MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE IMLAAKKGLD 
61:	PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV VWFWLHKGEA QRCPRCGAHY 
121:	KLVPQQLAH