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3.D.4.11.1
Cytochrome oxidase (Cox or CcO).  Reversible hydration-level changes of the cavity can be a key factor that regulates the branching of proton transfer events and therefore contributes to the vectorial efficiency of proton transport (Son et al. 2017). Cox16 is required for the assembly of the mitochondrial cytochrome c oxidase (respiratory chain complex IV (CIV)), possibly by promoting the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (Cerqua et al. 2018; Aich et al. 2018). Lipid composition affects the efficiency of the functional reconstitution of the cytochrome c oxidase (Hugentobler et al. 2020). The DeepCys program has been used to predict the functions of cysteine residues in Cox2 (Nallapareddy et al. 2021).

Accession Number:P13073
Protein Name:CoxIV-1
Length:169
Molecular Weight:19577.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate hydron

Cross database links:

RefSeq: NP_001852.1   
Entrez Gene ID: 1327   
Pfam: PF02936   
OMIM: 123864  gene
KEGG: hsa:1327   

Gene Ontology

GO:0005743 C:mitochondrial inner membrane
GO:0005634 C:nucleus
GO:0004129 F:cytochrome-c oxidase activity
GO:0005515 F:protein binding
GO:0006091 P:generation of precursor metabolites and energy

References (7)

[1] “Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase.”  Zeviani M.et.al.   2444497
[2] “Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV.”  Lomax M.I.et.al.   2157630
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4.”  Bachman N.J.et.al.   10337626
[6] “Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform.”  van Kuilenburg A.B.P.et.al.   1311608
[7] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
Structure:
5Z62     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK 
61:	ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW 
121:	QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV NPIQGLASKW DYEKNEWKK