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2.A.6.1.2
Heavy metal (Co2+, Zn2+, Cd2+) efflux pump, CzcAB.  Functions with CzcC (P13509; 1.B.17.2.2).

Accession Number:P13511
Protein Name:CzcA
Length:1063
Molecular Weight:115644.00
Species:Alcaligenes eutrophus (Ralstonia eutropha) [266264]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate cadmium(2+), cobalt(2+), zinc(2+)

Cross database links:

RefSeq: YP_145595.1    YP_581789.1   
Entrez Gene ID: 3170373    4036515   
Pfam: PF00873   
BioCyc: RMET266264:RMET_5980-MONOMER   
KEGG: rme:Rmet_5980   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0006812 P:cation transport
GO:0046686 P:response to cadmium ion

References (2)

[1] “Expression and nucleotide sequence of a plasmid-determined divalent cation efflux system from Alcaligenes eutrophus.”  Nies D.H.et.al.   2678100
[2] “The czc operon of Alcaligenes eutrophus CH34: from resistance mechanism to the removal of heavy metals.”  Diels L.et.al.   7766206

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MFERIISFAI QQRWLVLLAV FGMAGLGIFS YNRLPIDAVP DITNVQVQVN TSAPGYSPLE 
61:	TEQRATYPIE VVMAGLPGLE QTRSLSRYGL SQVTVIFKDG TDVYFARQLV NQRIQEAKDN 
121:	LPEGVVPAMG PISTGLGEIY LWTVEAEEGA RKADGTAYTP TDLREIQDWV VRPQLRNVPG 
181:	VTEINTIGGF NKQYLVAPSL ERLASYGLTL TDVVNALNKN NDNVGAGYIE RRGEQYLVRA 
241:	PGQVASEDDI RNIIVGTAQG QPIRIRDIGD VEIGKELRTG AATENGKEVV LGTVFMLIGE 
301:	NSRAVSKAVD EKVASINRTM PEGVKIVTVY DRTRLVDKAI ATVKKNLLEG AVLVIVILFL 
361:	FLGNIRAALI TATIIPLAML FTFTGMVNYK ISANLMSLGA LDFGIIIDGA VVIVENCVRR 
421:	LAHAQEHHGR PLTRSERFHE VFAAAKEARR PLIFGQLIIM IVYLPIFALT GVEGKMFHPM 
481:	AFTVVLALLG AMILSVTFVP AAVALFIGER VAEKENRLML WAKRRYEPLL EKSLANTAVV 
541:	LTFAAVSIVL CVAIAARLGS EFIPNLNEGD IAIQALRIPG TSLSQSVEMQ KTIETTLKAK 
601:	FPEIERVFAR TGTAEIASDL MPPNISDGYI MLKPEKDWPE PKKTHAELLS AIQEEAGKIP 
661:	GNNYEFSQPI QLRFNELISG VRSDVAVKIF GDDNNVLSET AKKVSAVLQG IPGAQEVKVE 
721:	QTTGLPMLTV KIDREKAARY GLNMSDVQDA VATGVGGRDS GTFFQGDRRF DIVVRLPEAV 
781:	RGEVEALRRL PIPLPKGVDA RTTFIPLSEV ATLEMAPGPN QISRENGKRR IVISANVRGR 
841:	DIGSFVPEAE AAIQSQVKIP AGYWMTWGGT FEQLQSATTR LQVVVPVALL LVFVLLFAMF 
901:	NNIKDGLLVF TGIPFALTGG ILALWIRGIP MSITAAVGFI ALCGVAVLNG LVMLSFIRSL 
961:	REEGHSLDSA VRVGALTRLR PVLMTALVAS LGFVPMAIAT GTGAEVQRPL ATVVIGGILS 
1021:	STALTLLVLP VLYRLAHRKD EDAEDTREPV TQTHQPDQGR QPA