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3.D.1.9.2 Hydrogenase 3, Hyc. Catalyzes H₂ production coupled to H⁺ export (Bagramyan et al., 2002). The HycC and HycD proteins span the membrane multiple times; FdhF is a molybdenum-dependent formate dehydrogenase while HycE (Hyd-3) is a NiFe hydrogenase (McDowall et al. 2014).
Accession Number:	P16429
Protein Name:	Formate hydrogenlyase subunit 3
Length:	608
Molecular Weight:	64077.00
Species:	Escherichia coli (strain K12) [83333]
Number of TMSs:	16
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	hydron

UniProt (Universal Protein Resource)
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FASTA formatted sequence

1:	MSAISLINSG VAWFVAAAVL AFLFSFQKAL SGWIAGIGGA VGSLYTAAAG FTVLTGAVGV 
61:	SGALSLVSYD VQISPLNAIW LITLGLCGLF VSLYNIDWHR HAQVKCNGLQ INMLMAAAVC 
121:	AVIASNLGMF VVMAEIMALC AVFLTSNSKE GKLWFALGRL GTLLLAIACW LLWQRYGTLD 
181:	LRLLDMRMQQ LPLGSDIWLL GVIGFGLLAG IIPLHGWVPQ AHANASAPAA ALFSTVVMKI 
241:	GLLGILTLSL LGGNAPLWWG IALLVLGMIT AFVGGLYALV EHNIQRLLAY HTLENIGIIL 
301:	LGLGAGVTGI ALEQPALIAL GLVGGLYHLL NHSLFKSVLF LGAGSVWFRT GHRDIEKLGG 
361:	IGKKMPVISI AMLVGLMAMA ALPPLNGFAG EWVIYQSFFK LSNSGAFVAR LLGPLLAVGL 
421:	AITGALAVMC MAKVYGVTFL GAPRTKEAEN ATCAPLLMSV SVVALAICCV IGGVAAPWLL 
481:	PMLSAAVPLP LEPANTTVSQ PMITLLLIAC PLLPFIIMAI CKGDRLPSRS RGAAWVCGYD 
541:	HEKSMVITAH GFAMPVKQAF APVLKLRKWL NPVSLVPGWQ CEGSALLFRR MALVELAVLV 
601:	VIIVSRGA

3.D.1.9.2
Hydrogenase 3, Hyc. Catalyzes H₂ production coupled to H⁺ export (Bagramyan et al., 2002). The HycC and HycD proteins span the membrane multiple times; FdhF is a molybdenum-dependent formate dehydrogenase while HycE (Hyd-3) is a NiFe hydrogenase (McDowall et al. 2014).

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3.D.1.9.2Hydrogenase 3, Hyc. Catalyzes H2 production coupled to H+ export (Bagramyan et al., 2002). The HycC and HycD proteins span the membrane multiple times; FdhF is a molybdenum-dependent formate dehydrogenase while HycE (Hyd-3) is a NiFe hydrogenase (McDowall et al. 2014).

Cross database links:

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3.D.1.9.2
Hydrogenase 3, Hyc. Catalyzes H₂ production coupled to H⁺ export (Bagramyan et al., 2002). The HycC and HycD proteins span the membrane multiple times; FdhF is a molybdenum-dependent formate dehydrogenase while HycE (Hyd-3) is a NiFe hydrogenase (McDowall et al. 2014).