Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.D.4.11.1
Cytochrome oxidase (Cox or CcO).  Reversible hydration-level changes of the cavity can be a key factor that regulates the branching of proton transfer events and therefore contributes to the vectorial efficiency of proton transport (Son et al. 2017). Cox16 is required for the assembly of the mitochondrial cytochrome c oxidase (respiratory chain complex IV (CIV)), possibly by promoting the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (Cerqua et al. 2018; Aich et al. 2018). Lipid composition affects the efficiency of the functional reconstitution of the cytochrome c oxidase (Hugentobler et al. 2020). The DeepCys program has been used to predict the functions of cysteine residues in Cox2 (Nallapareddy et al. 2021).

Accession Number:P20674
Protein Name:CoxVa
Length:150
Molecular Weight:16762.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate hydron

Cross database links:

RefSeq: NP_004246.2   
Entrez Gene ID: 9377   
Pfam: PF02284   
OMIM: 603773  gene
KEGG: hsa:9377   

Gene Ontology

GO:0005743 C:mitochondrial inner membrane
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0046872 F:metal ion binding

References (6)

[1] “Subunit Va of human and bovine cytochrome c oxidase is highly conserved.”  Rizzuto R.et.al.   2853101
[2] “Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.”  Uddin M.et.al.   18197981
[3] “Analysis of the DNA sequence and duplication history of human chromosome 15.”  Zody M.C.et.al.   16572171
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Human liver protein map: update 1993.”  Hughes G.J.et.al.   8313870
[6] “The major protein expression profile and two-dimensional protein database of human heart.”  Kovalyov L.I.et.al.   7498159
Structure:
5Z62     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE EFDARWVTYF 
61:	NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN DFASTVRILE VVKDKAGPHK 
121:	EIYPYVIQEL RPTLNELGIS TPEELGLDKV