9.A.63.1.1
The yeast retromer-dependent Vacuolar Protein Sorting (VPS) apparatus (Feyder et al. 2015). The sorting nexin (SNX) proteins, homologous to retromer-dependent VPS protein, Q92331, that normally function in endosomal membrane trafficking, are a major class of inclusion-associated host proteins in chlamydial infection (Paul et al. 2017). Some of the components of this system are homologous to those of the retromer complexes in animals (see 9.A.3; McNally and Cullen 2018). VPS1, a GTPase involved in membrane fusion/fission, of 704 aas, may be involved in Coenzyme Q uptake and trafficking (Guile et al. 2023). The dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site (Hu and Reggiori 2023). The yeast dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site in Saccharomyces cerevisiae (Hu and Reggiori 2023).
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| Accession Number: | P21576 |
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| Protein Name: | Vacuolar protein sorting-associated protein 1 |
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| Length: | 704 |
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| Molecular Weight: | 78737.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
protein polypeptide chain |
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1: MDEHLISTIN KLQDALAPLG GGSQSPIDLP QITVVGSQSS GKSSVLENIV GRDFLPRGTG
61: IVTRRPLVLQ LINRRPKKSE HAKVNQTANE LIDLNINDDD KKKDESGKHQ NEGQSEDNKE
121: EWGEFLHLPG KKFYNFDEIR KEIVKETDKV TGANSGISSV PINLRIYSPH VLTLTLVDLP
181: GLTKVPVGDQ PPDIERQIKD MLLKYISKPN AIILSVNAAN TDLANSDGLK LAREVDPEGT
241: RTIGVLTKVD LMDQGTDVID ILAGRVIPLR YGYIPVINRG QKDIEHKKTI REALENERKF
301: FENHPSYSSK AHYCGTPYLA KKLNSILLHH IRQTLPEIKA KIEATLKKYQ NELINLGPET
361: MDSASSVVLS MITDFSNEYA GILDGEAKEL SSQELSGGAR ISYVFHETFK NGVDSLDPFD
421: QIKDSDIRTI MYNSSGSAPS LFVGTEAFEV LVKQQIRRFE EPSLRLVTLV FDELVRMLKQ
481: IISQPKYSRY PALREAISNQ FIQFLKDATI PTNEFVVDII KAEQTYINTA HPDLLKGSQA
541: MVMVEEKLHP RQVAVDPKTG KPLPTQPSSS KAPVMEEKSG FFGGFFSTKN KKKLAALESP
601: PPVLKATGQM TERETMETEV IKLLISSYFS IVKRTIADII PKALMLKLIV KSKTDIQKVL
661: LEKLYGKQDI EELTKENDIT IQRRKECKKM VEILRNASQI VSSV