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3.D.4.11.1
Cytochrome oxidase (Cox or CcO).  Reversible hydration-level changes of the cavity can be a key factor that regulates the branching of proton transfer events and therefore contributes to the vectorial efficiency of proton transport (Son et al. 2017). Cox16 is required for the assembly of the mitochondrial cytochrome c oxidase (respiratory chain complex IV (CIV)), possibly by promoting the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (Cerqua et al. 2018; Aich et al. 2018). Lipid composition affects the efficiency of the functional reconstitution of the cytochrome c oxidase (Hugentobler et al. 2020). The DeepCys program has been used to predict the functions of cysteine residues in Cox2 (Nallapareddy et al. 2021).

Accession Number:P24310
Protein Name:CoxVIIa-H aka CoxVIIa-M
Length:79
Molecular Weight:9118.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate hydron

Cross database links:

RefSeq: NP_001855.1   
Entrez Gene ID: 1346   
Pfam: PF02238   
OMIM: 123995  gene
KEGG: hsa:1346   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005746 C:mitochondrial respiratory chain
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0006091 P:generation of precursor metabolites and energy

References (7)

[1] “Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase.”  Arnaudo E.et.al.   1327965
[2] “Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M.”  Wolz W.et.al.   9344674
[3] “Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH).”  Yu M.et.al.   11997101
[4] “Molecular evolution of the COX7A gene family in primates.”  Schmidt T.R.et.al.   10335655
[5] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.”  van Kuilenburg A.B.P.et.al.   1309697

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FASTA formatted sequence 
1:	MQALRVSQAL IRSFSSTARN RFQNRVREKQ KLFQEDNDIP LYLKGGIVDN ILYRVTMTLC 
61:	LGGTVYSLYS LGWASFPRN