Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.2.1.2
Na+-translocating F-type ATPase/ATP synthase of 8 subunits.  The Fo-a subunit plays a role in Na+ transport. It forms half channels that allow Na+ to enter and leave the buried carboxyl group on the Fo-c subunits. The essential Arg residue, R226, which faces the carboxyl group of Fo-c subunits in the middle of transmembrane helix 5 of the Fo-a subunit, separates the cytoplasmic side and periplasmic half-channels (Mitome et al. 2017). Residues that contribute to the integrity of the Na+ half channels have been identified; both half channels are present in the Fo-a subunit (Mitome et al. 2017).

Accession Number:P29707
Protein Name:ATPB aka ATPD aka UNCD
Length:467
Molecular Weight:50850.00
Species:Propionigenium modestum [2333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate sodium(1+)

Cross database links:

Pfam: PF00006    PF00306    PF02874   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0045261 C:proton-transporting ATP synthase complex, c...
GO:0005524 F:ATP binding
GO:0046933 F:hydrogen ion transporting ATP synthase acti...
GO:0008553 F:hydrogen-exporting ATPase activity, phospho...
GO:0046961 F:proton-transporting ATPase activity, rotati...
GO:0042777 P:plasma membrane ATP synthesis coupled proto...
GO:0006814 P:sodium ion transport

References (2)

[1] “In vivo synthesis of ATPase complexes of Propionigenium modestum and Escherichia coli and analysis of their function.”  Gerike U.et.al.   7556212
[2] “N-terminal amino acid sequences of the subunits of the Na(+)-translocating F1F0 ATPase from Propionigenium modestum.”  Gerike U.et.al.   8422943

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MENKGVITQI IGPVVDVTFE NELPRIYNAL KIDRGNGEYL VAEVQQHLGN SVVRAVAMDA 
61:	TDGLQRGMEV VDTGPAITVP VGKAVLGRIL NVLGEPVDEA GEVKAEEYAP IHREAPAFED 
121:	QGTEKEVFET GIKVVDLLAP YVKGGKIGLF GGAGVGKTVL IMELINNIAQ GHGGLSVFAG 
181:	VGERTREGRD LYDEMLESGV LDKTSLVYGQ MNEPPGARLR VGLTGLTMAE NFRDKEGQDV 
241:	LFFVDNIFRF TQAPSEVSAL LGRMPSAVGY QPNLATDMGA LQERITSTKT GSITSVQAVY 
301:	VPADDLTDPA PATTFTHLDA TTVLSRRIAS LGIYPAVDPL DSTSTALEPQ IIGHEHYNTA 
361:	REVQQILQRY KELQDIIAIL GMDELSDEDK VTVNRARKIE RFFSQPFHVA EQFTGMDGKY 
421:	VTVKETIRGF KEIIEGKHDD LPEQAFLYVG TIDEAIAKAR ELMKGAE