9.A.63.1.1
The yeast retromer-dependent Vacuolar Protein Sorting (VPS) apparatus (Feyder et al. 2015). The sorting nexin (SNX) proteins, homologous to retromer-dependent VPS protein, Q92331, that normally function in endosomal membrane trafficking, are a major class of inclusion-associated host proteins in chlamydial infection (Paul et al. 2017). Some of the components of this system are homologous to those of the retromer complexes in animals (see 9.A.3; McNally and Cullen 2018). VPS1, a GTPase involved in membrane fusion/fission, of 704 aas, may be involved in Coenzyme Q uptake and trafficking (Guile et al. 2023). The dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site (Hu and Reggiori 2023). The yeast dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site in Saccharomyces cerevisiae (Hu and Reggiori 2023).
|
| Accession Number: | P32319 |
|---|
| Protein Name: | Vacuolar protein sorting/targeting protein VPS10 |
|---|
| Length: | 1579 |
|---|
| Molecular Weight: | 177777.00 |
|---|
| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
|---|
| Number of TMSs: | 2 |
|---|
| Location1 / Topology2 / Orientation3: |
Golgi apparatus1 / Single-pass type I membrane protein2 |
|---|
| Substrate |
protein polypeptide chain |
|---|
1: MILLHFVYSL WALLLIPLTN AEEFTPKVTK TIAQDSFDIL SFDDSNTLIR KQDTSVTISF
61: DDGETWEKVE GIEGEITWIY IDPFNRHDRA VATAMNGSYL YITNDQGKSW ERITLPDSGE
121: SISPRECYIE THPLNKNYFL AKCNYCEKTE VNNDNEENSG DEEGQFEIFN ITRCTDKVFA
181: SNDGGKSFSE IKSSLERNEN SPISISDCGF AKTSKDSDLE SSDTSIICLF QNMQLIMDEF
241: SSPYTESKLV LTTDWGKSLK EFDQFKDKVV NGYRILKSHM VVLTQGDRYN DMSSMDVWVS
301: NDLSNFKMAY MPTQLRHSMQ GEIYEDAMGR IILPMSRERS DQEEDKGIVS EILISDSQGL
361: KFSPIPWTAN EVFGYINFYQ PTYLKGTMIA SLYPLSRRRN RKGKAKGVKS KGVTKISVDN
421: GLTWTMLKVV DPDNADSFDC DITDFENCSL QNMFYTREGS TPTAGILMTT GIVGDGSVFD
481: WGDQRTFISR DGGLTWKLAF DFPCLYAVGD YGNVIVAIPY NADEDDDPQS EFYYSLDQGK
541: TWTEYQLETT IYPNEVMNTT PDGSGAKFIL NGFTLAHMDG TTNFIYAIDF STAFNDKTCE
601: ENDFEDWNLA EGKCVNGVKY KIRRRKQDAQ CLVKKVFEDL QLFETACDKC TEADYECAFE
661: FVRDATGKCV PDYNLIVLSD VCDKTKKKTV PVKPLQLVKG DKCKKPMTVK SVDISCEGVP
721: KKGTNDKEIV VTENKFDFKI QFYQYFDTVT DESLLMINSR GEAYISHDGG QTIKRFDSNG
781: ETIIEVVFNP YYNSSAYLFG SKGSIFSTHD RGYSFMTAKL PEARQLGMPL DFNAKAQDTF
841: IYYGGKNCES ILSPECHAVA YLTNDGGETF TEMLDNAIHC EFAGSLFKYP SNEDMVMCQV
901: KEKSSQTRSL VSSTDFFQDD KNTVFENIIG YLSTGGYIIV AVPHENNELR AYVTIDGTEF
961: AEAKFPYDED VGKQEAFTIL ESEKGSIFLH LATNLVPGRD FGNLLKSNSN GTSFVTLEHA
1021: VNRNTFGYVD FEKIQGLEGI ILTNIVSNSD KVAENKEDKQ LKTKITFNEG SDWNFLKPPK
1081: RDSEGKKFSC SSKSLDECSL HLHGYTERKD IRDTYSSGSA LGMMFGVGNV GPNLLPYKEC
1141: STFFTTDGGE TWAEVKKTPH QWEYGDHGGI LVLVPENSET DSISYSTDFG KTWKDYKFCA
1201: DKVLVKDITT VPRDSALRFL LFGEAADIGG SSFRTYTIDF RNIFERQCDF DITGKESADY
1261: KYSPLGSKSN CLFGHQTEFL RKTDENCFIG NIPLSEFSRN IKNCSCTRQD FECDYNFYKA
1321: NDGTCKLVKG LSPANAADVC KKEPDLIEYF ESSGYRKIPL STCEGGLKLD APSSPHACPG
1381: KEKEFKEKYS VSAGPFAFIF ISILLIIFFA AWFVYDRGIR RNGGFARFGE IRLGDDGLIE
1441: NNNTDRVVNN IVKSGFYVFS NIGSLLQHTK TNIAHAISKI RGRFGNRTGP SYSSLIHDQF
1501: LDEADDLLAG HDEDANDLSS FMDQGSNFEI EEDDVPTLEE EHTSYTDQPT TTDVPDTLPE
1561: GNEENIDRPD STAPSNENQ