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9.A.50.1.1 The tRNA nuclear export machinery, t-Exporter. Includes UTP8, a tRNA-binding protein, Los1 and Msn5/ two tRNA export receptors (Strub et al., 2007). Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5 has been reported (Fung et al. 2025).
Accession Number:	P32835
Protein Name:	GSP1/CNR1
Length:	219
Molecular Weight:	24810.00
Species:	Saccharomyces cerevisiae [4932]
Location¹ / Topology² / Orientation³:	Nucleus¹
Substrate	protein, transfer RNA

Structure:
DIP:	DIP-747N
RefSeq:	NP_013396.1
Entrez Gene ID:	851000
Pfam:	PF00071
KEGG:	sce:YLR293C
Gene Ontology GO:0005737 C:cytoplasm GO:0005634 C:nucleus GO:0005525 F:GTP binding GO:0003924 F:GTPase activity GO:0005515 F:protein binding GO:0000467 P:exonucleolytic trimming to generate mature ... GO:0006886 P:intracellular protein transport GO:0006913 P:nucleocytoplasmic transport GO:0006997 P:nucleus organization GO:0031938 P:regulation of chromatin silencing at telomere GO:0007165 P:signal transduction
References (9) [1] “Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.” Kadowaki T.et.al. 7687541 [2] “GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization.” Belhumeur P.et.al. 8455603 [3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.” Johnston M.et.al. 9169871 [4] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.” Hu Y.et.al. 17322287 [5] “Protein identifications for a Saccharomyces cerevisiae protein database.” Garrels J.I.et.al. 7895733 [6] “Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1.” Noguchi E.et.al. 8896453 [7] “Overexpression of Bud5p can suppress mutations in the Gsp1p guanine nucleotide exchange factor Prp20p in Saccharomyces cerevisiae.” Clement M.et.al. 11589573 [8] “A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits.” Oeffinger M.et.al. 14729571 [9] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.” Albuquerque C.P.et.al. 18407956
2X19 3ICQ 3M1I 3WYG

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSAPAANGEV PTFKLVLVGD GGTGKTTFVK RHLTGEFEKK YIATIGVEVH PLSFYTNFGE 
61:	IKFDVWDTAG QEKFGGLRDG YYINAQCAII MFDVTSRITY KNVPNWHRDL VRVCENIPIV 
121:	LCGNKVDVKE RKVKAKTITF HRKKNLQYYD ISAKSNYNFE KPFLWLARKL AGNPQLEFVA 
181:	SPALAPPEVQ VDEQLMQQYQ QEMEQATALP LPDEDDADL

9.A.50.1.1
The tRNA nuclear export machinery, t-Exporter. Includes UTP8, a tRNA-binding protein, Los1 and Msn5/ two tRNA export receptors (Strub et al., 2007). Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5 has been reported (Fung et al. 2025).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

9.A.50.1.1The tRNA nuclear export machinery, t-Exporter. Includes UTP8, a tRNA-binding protein, Los1 and Msn5/ two tRNA export receptors (Strub et al., 2007). Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5 has been reported (Fung et al. 2025).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

9.A.50.1.1
The tRNA nuclear export machinery, t-Exporter. Includes UTP8, a tRNA-binding protein, Los1 and Msn5/ two tRNA export receptors (Strub et al., 2007). Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5 has been reported (Fung et al. 2025).