1.F.2.1.1
Yeast 8 subunit exocyst complex involved in tethering before membrane fusion between vesicles and the plasma membrane (Zárský et al. 2013). Subunits include Sec3, 1336 aas, Sec5, 971 aas, Sec6, 805 aas, Sec8, 1065 aas, Sec10, 871 aas, Sec15, 910 aas, Exo70, 623 aas and Exo84, 753 aas. Exosomes can function as nano-shuttles bearing, for example, therapeutic biomolecules (Masjedi et al. 2024).
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| Accession Number: | P32855 |
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| Protein Name: | Exocyst complex component SEC8 |
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| Length: | 1065 |
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| Molecular Weight: | 122225.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
molecule |
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1: MDYLKPAQKG RRRGLSINSL SETQQSAMNS SLDHLQNDLN RINLQWNRIL SDNTNPLELA
61: LAFLDDTSVG LGHRYEEFNQ LKSQIGSHLQ DVVNEHSQVF NTNVASYGKA VSSIMQAQEQ
121: TLNLKNCLKE ANEKITTDKG SLQELNDNNL KYTKMIDVLV NIEELLQIPE KIEENIRKEN
181: FHQVQILLER GFILMNNKSL KTVEILKPIN QQLELQEHLL FNNLIEEIHD IMYSKSNKTN
241: FTRVTNNDIF KIISISHNGF TSLENYLYNI VNIDIMEHSK TINKNLEQFI HDQSLNKGNI
301: MLQENAATQA PLAPSRNQEN EGFNRIGFLL KTINNINKLP VAFNIITERA KEEIHNIIVK
361: STESIRSKHP SLLKMATSLK NDNHFGLPVQ DILSIILREC FWEIFLKLLY AIQCHRAIFE
421: MSNILQPTSS AKPAFKFNKI WGKLLDEIEL LLVRYINDPE LISSNNGSIK PINGATNNAP
481: TLPKRKNPKI FSLEYNIEDN SSVKDQAFEL KALLKDIFPG FSVSSNMDLD SIYVKDESFE
541: QDEPLVPPSV FNMKVILDPF LLFTQSTSTI VPSVLTQNTI SSLTFFDDYM NKSFLPKIQM
601: TMDYLFTVEV ESNNPYALEL SDENHNIFKT ALDFQRLFYN LLNVFNTANT FREKISYCIL
661: DLLNHFYNYY LGLFNSLIGT SDRHLTRKII TAWLQNGILM DQEQKILNGD ETLFHEESIE
721: LFKEIPHFYQ AGKGLSKSDL FNNLTLDTIL QFSASVLWIL NWLPGLKKAI NIDEVSQEPM
781: LDADRLRSSW TFSESMDLNY SNPSSSPNSL GNLKILLDDK ASKKFDETID GFKTLKFKLI
841: TILRFNIRAL CIYDIGSFFQ NTKIWNMDVG SIELDQNIAS LISELRRTES KLKQQLPEKE
901: KNSIFIGLDI VNNYALIKGA KSIKVLNHNG IKKMLRNVNV LQHAYRNLSS EPSKINMNVT
961: MNFYSLCGSS EAELFEYIKD NELPHCSVED LKTILRLQFS EEMHRQLKRQ STSSTKGSIK
1021: PSNKRYTEAL EKLSNLEKEQ SKEGARTKIG KLKSKLNAVH TANEK