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| Accession Number: | P33418 |
| Protein Name: | Los1 |
| Length: | 1100 |
| Molecular Weight: | 126820.00 |
| Species: | Saccharomyces cerevisiae [4932] |
| Location1 / Topology2 / Orientation3: | Nucleus1 |
| Substrate | protein, transfer RNA |
Cross database links:
| DIP: | DIP-760N |
|---|---|
| RefSeq: | NP_012717.1 |
| Entrez Gene ID: | 853630 |
| Pfam: | PF08389 |
| KEGG: | sce:YKL205W |
Gene Ontology
GO:0005739
C:mitochondrion
GO:0016363
C:nuclear matrix
GO:0008536
F:Ran GTPase binding
GO:0000049
F:tRNA binding
GO:0071528
P:tRNA re-export from nucleus
GO:0006388
P:tRNA splicing, via endonucleolytic cleavage...
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References (20)[1] “The Saccharomyces cerevisiae LOS1 gene involved in pre-tRNA splicing encodes a nuclear protein that behaves as a component of the nuclear matrix.” Shen W.-C.et.al. 8366091 [2] “Complete DNA sequence of yeast chromosome XI.” Dujon B.et.al. 8196765 [3] “Processing of intervening sequences: a new yeast mutant which fails to excise intervening sequences from precursor tRNAs.” Hopper A.K.et.al. 7363329 [4] “Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing.” Hurt D.J.et.al. 3031485 [5] “Nuclear pore proteins are involved in the biogenesis of functional tRNA.” Simos G.et.al. 8641292 [6] “Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family.” Shen W.-C.et.al. 8725220 [7] “tRNA nuclear export in saccharomyces cerevisiae: in situ hybridization analysis.” Sarkar S.et.al. 9802895 [8] “Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA.” Hellmuth K.et.al. 9774653 [9] “A novel in vivo assay reveals inhibition of ribosomal nuclear export in ran-cycle and nucleoporin mutants.” Hurt E.C.et.al. 9971735 [10] “Nucleotides of the tRNA D-stem that play an important role in nuclear-tRNA export in Saccharomyces cerevisiae.” Cleary J.D.et.al. 10727409 [11] “An aminoacylation-dependent nuclear tRNA export pathway in yeast.” Grosshans H.et.al. 10766739 [12] “Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.” Qiu H.et.al. 10713174 [13] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [14] “The nuclear tRNA aminoacylation-dependent pathway may be the principal route used to export tRNA from the nucleus in Saccharomyces cerevisiae.” Steiner-Mosonyi M.et.al. 14640976 [15] “Retrograde movement of tRNAs from the cytoplasm to the nucleus in Saccharomyces cerevisiae.” Shaheen H.H.et.al. 16040803 [16] “tRNA actively shuttles between the nucleus and cytosol in yeast.” Takano A.et.al. 15905365 [17] “The localization of nuclear exporters of the importin-beta family is regulated by Snf1 kinase, nutrient supply and stress.” Quan X.et.al. 17544521 [18] “Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint.” Ghavidel A.et.al. 18045534 [19] “Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery.” McGuire A.T.et.al. 17203074 [20] “Utp8p is a nucleolar tRNA-binding protein that forms a complex with components of the nuclear tRNA export machinery in Saccharomyces cerevisiae.” Strub B.R.et.al. 17634288
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MLERIQQLVN AVNDPRSDVA TKRQAIELLN GIKSSENALE IFISLVINEN SNDLLKFYGL 61: STLIELMTEG VNANPNGLNL VKFEITKWLK FQVLGNKQTK LPDFLMNKIS EVLTTLFMLM 121: YSDCNGNQWN SFFDDLMSLF QVDSAISNTS PSTDGNILLG LEFFNKLCLM INSEIADQSF 181: IRSKESQLKN NNIKDWMRDN DIMKLSNVWF QCLKLDEQIV SQCPGLINST LDCIGSFISW 241: IDINLIIDAN NYYLQLIYKF LNLKETKISC YNCILAIISK KMKPMDKLAF LNMINLTNEL 301: TYYHQAISMN PQIITFDNLE VWESLTKLIT SFGIEFTIII EQVNDDQKLD TLYKQSVISN 361: VDSILLEKII PILLEFMNNE FDSITAKTFP FWSNYLAFLK KYKASSPNFV PLHKDFLDNF 421: QQICFKRMKF SDDEVTQDDF EEFNETVRFK LKNFQEIIVV IDPSLFLNNI SQEISANLMN 481: CKNESWQIFE LTIYQIFNLS ECTKNNYFGL NKNEIMTSQP SLTLVRFLNE LLMMKDFLLA 541: IDNEQIQILF MELIVKNYNF IFSTSANTAN ATDDDEKYLL ILNIFMSSFA MFNKRENVRL 601: RSWYLFTRFL KLTRINLKKI LFANKNLVNE ITNKISPLLH IKVTSINAQG TDDNDTIFDN 661: QLYIFEGIGF IITLNNSSQE LTAATANTPI DYDILDQILT PLFTQLEGCI TQGASPVVIL 721: ECHHILMAIG TLARGLHIGL VPENQVNNMV VNKKLINDSL IHKFSNIAEV ILVTFSFFNK 781: FENIRDASRF TFARLIPILS NKILPFINKL IELILSSTDL KSWEMIDFLG FLSQLIHMFH 841: TDTDCYQLFN QLLTPLINKV HSIIEEIDEQ HDQQSSSNKP IDTAVTATSV NKNIVVTDSY 901: RDKILLKKAY CTFLQSFTNN SVTSILLSDI NRAILPVILN DLVTYTPQEI QETSMMKVSL 961: NVLCNFIKCF GNGTCLDNDD INKDPNLKID GLNEYFIMKC VPIIFEIPFN PIYKFNIKEG 1021: NFKTMAYDLA RLLRELFIVS SNPTTNENEC VKYLTQIYLP QIQLPQELTI QLVNMLTTMG 1081: QKQFEKWFVD NFISVLKQGQ