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3.A.1.5.3
Nickel porter. Histidine 416 of NikA is essential for nickel uptake (Cavazza et al., 2011).

Accession Number:P33590
Protein Name:NikA aka B3476
Length:524
Molecular Weight:58719.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Periplasm1
Substrate nickel(2+)

Cross database links:

DIP: DIP-10340N
RefSeq: AP_004316.1    NP_417933.1   
Entrez Gene ID: 947981   
Pfam: PF00496   
BioCyc: EcoCyc:NIKA-MONOMER    ECOL168927:B3476-MONOMER   
KEGG: ecj:JW3441    eco:b3476   

Gene Ontology

GO:0042597 C:periplasmic space
GO:0020037 F:heme binding
GO:0016151 F:nickel ion binding
GO:0005215 F:transporter activity
GO:0050919 P:negative chemotaxis
GO:0006810 P:transport

References (5)

[1] “The nik operon of Escherichia coli encodes a periplasmic binding-protein-dependent transport system for nickel.”  Navarro C.et.al.   7934931
[2] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Crystal structures of the liganded and unliganded nickel-binding protein NikA from Escherichia coli.”  Heddle J.et.al.   12960164
Structure:
1UIU   1UIV   1ZLQ   2NOO   3DP8   3E3K   3MVW   3MVX   3MVY   3MVZ   [...more]

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MLSTLRRTLF ALLACASFIV HAAAPDEITT AWPVNVGPLN PHLYTPNQMF AQSMVYEPLV 
61:	KYQADGSVIP WLAKSWTHSE DGKTWTFTLR DDVKFSNGEP FDAEAAAENF RAVLDNRQRH 
121:	AWLELANQIV DVKALSKTEL QITLKSAYYP FLQELALPRP FRFIAPSQFK NHETMNGIKA 
181:	PIGTGPWILQ ESKLNQYDVF VRNENYWGEK PAIKKITFNV IPDPTTRAVA FETGDIDLLY 
241:	GNEGLLPLDT FARFSQNPAY HTQLSQPIET VMLALNTAKA PTNELAVREA LNYAVNKKSL 
301:	IDNALYGTQQ VADTLFAPSV PYANLGLKPS QYDPQKAKAL LEKAGWTLPA GKDIREKNGQ 
361:	PLRIELSFIG TDALSKSMAE IIQADMRQIG ADVSLIGEEE SSIYARQRDG RFGMIFHRTW 
421:	GAPYDPHAFL SSMRVPSHAD FQAQQGLADK PLIDKEIGEV LATHDETQRQ ALYRDILTRL 
481:	HDEAVYLPIS YISMMVVSKP ELGNIPYAPI ATEIPFEQIK PVKP