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3.A.1.5.3
Nickel porter. Histidine 416 of NikA is essential for nickel uptake (Cavazza et al., 2011).

Accession Number:P33591
Protein Name:NikB aka B3477
Length:314
Molecular Weight:35248.00
Species:Escherichia coli [83333]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate nickel(2+)

Cross database links:

DIP: DIP-10341N
RefSeq: AP_004315.1    NP_417934.1   
Entrez Gene ID: 947986   
Pfam: PF00528   
BioCyc: EcoCyc:NIKB-MONOMER    ECOL168927:B3477-MONOMER   
KEGG: ecj:JW3442    eco:b3477   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0015675 P:nickel ion transport

References (5)

[1] “The nik operon of Escherichia coli encodes a periplasmic binding-protein-dependent transport system for nickel.”  Navarro C.et.al.   7934931
[2] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MLRYVLRRFL LLIPMVLAAS VIIFLMLRLG TGDPALDYLR LSNLPPTPEM LASTRTMLGL 
61:	DQPLYVQYGT WLWKALHLDF GISFASQRPV LDDMLNFLPA TLELAGAALV LILLTSVPLG 
121:	IWAARHRDRL PDFAVRFIAF LGVSMPNFWL AFLLVMAFSV YLQWLPAMGY GGWQHIILPA 
181:	VSIAFMSLAI NARLLRASML DVAGQRHVTW ARLRGLNDKQ TERRHILRNA SLPMITAVGM 
241:	HIGELIGGTM IIENIFAWPG VGRYAVSAIF NRDYPVIQCF TLMMVVVFVV CNLIVDLLNA 
301:	ALDPRIRRHE GAHA