9.B.142.3.14
The glycosyltransferase complex consisting of 8 subunits, all integral membrane proteins. The high resolution 3-dimensional structure has been elucidated (Wild et al. 2018). The catalytic subunit is the STT3 protein of 718 aas and 13 TMSs. The other subunits have 1 - 6 TMSs. The function of the complex is glycosylation of newly synthesized proteins on Asn with Glc3Man9 GlcNac2.
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| Accession Number: | P33767 |
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| Protein Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1 |
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| Length: | 430 |
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| Molecular Weight: | 49392.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MRTDWNFFFC ILLQAIFVVG TQTSRTLVLY DQSTEPLEEY SVYLKDLEQR NYKLEYLDIN
61: STSTTVDLYD KEQRLFDNII VFPTKGGKNL ARQIPVKQLI KFFENEGNIL CMSSPGAVPN
121: TIRLFLNELG IYPSPKGHVI RDYFSPSSEE LVVSSNHLLN KYVYNARKSE DFVFGESSAA
181: LLENREQIVP ILNAPRTSFT ESKGKCNSWT SGSQGFLVVG FQNLNNARLV WIGSSDFLKN
241: KNQDSNQEFA KELLKWTFNE KSVIKSVHAV HSHADGTSYD EEPYKIKDKV IYSVGFSEWN
301: GEEWLPHIAD DIQFELRQVD PYYRLTLSPS GNDSETQYYT TGEFILPDRH GVFTFLTDYR
361: KIGLSFTTDK DVKAIRHLAN DEYPRSWEIS NSWVYISAIC GVIVAWIFFV VSFVTTSSVG
421: KKLETFKKTN