9.A.63.1.1
The yeast retromer-dependent Vacuolar Protein Sorting (VPS) apparatus (Feyder et al. 2015). The sorting nexin (SNX) proteins, homologous to retromer-dependent VPS protein, Q92331, that normally function in endosomal membrane trafficking, are a major class of inclusion-associated host proteins in chlamydial infection (Paul et al. 2017). Some of the components of this system are homologous to those of the retromer complexes in animals (see 9.A.3; McNally and Cullen 2018). VPS1, a GTPase involved in membrane fusion/fission, of 704 aas, may be involved in Coenzyme Q uptake and trafficking (Guile et al. 2023). The dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site (Hu and Reggiori 2023). The yeast dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site in Saccharomyces cerevisiae (Hu and Reggiori 2023).
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| Accession Number: | P34110 |
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| Protein Name: | Vacuolar protein sorting-associated protein 35 |
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| Length: | 944 |
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| Molecular Weight: | 109142.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Peripheral membrane protein2 |
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| Substrate |
protein polypeptide chain |
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1: MAYADSPENA IAVIKQRTAL MNRCLSQHKL MESLQHTSIM LTELRNPNLS PKKYYELYVI
61: IFDSLTNLST YLIENHPQNH HLADLYELVQ YTGNVVPRLY LMITVGTSYL TFNEAPKKEI
121: LKDMIEMCRG VQNPIRGLFL RYYLSQRTKE LLPEDDPSFN SQFIMNNFIE MNKLWVRLQH
181: QGPLRERETR TRERKELQIL VGSQLVRLSQ IIDDNFQMYK QDILPTILEQ VIQCRDLVSQ
241: EYLLDVICQV FADEFHLKTL DTLLQTTLHL NPDVSINKIV LTLVDRLNDY VTRQLEDDPN
301: ATSTNAYLDM DVFGTFWDYL TVLNHERPDL SLQQFIPLVE SVIVLSLKWY PNNFDNLNKL
361: FELVLQKTKD YGQKNISLES EHLFLVLLSF QNSKLQLTSS TTAPPNSPVT SKKHFIFQLI
421: SQCQAYKNIL ALQSISLQKK VVNEIIDILM DREVEEMADN DSESKLHPPG HSAYLVIEDK
481: LQVQRLLSIC EPLIISRSGP PANVASSDTN VDEVFFNRHD EEESWILDPI QEKLAHLIHW
541: IMNTTSRKQT MKNKIQFSLE AQLEILLLIK SSFIKGGINV KYTFPAIITN FWKLMRKCRM
601: IQEYLLKKRP DNKTLLSHYS NLLKQMFKFV SRCINDIFNS CNNSCTDLIL KLNLQCAILA
661: DQLQLNEISY DFFSQAFTIF EESLSDSKTQ LQALIYIAQS LQKTRSLYKE AYYDSLIVRC
721: TLHGSKLLKK QDQCRAVYLC SHLWWATEIS NIGEEEGITD NFYRDGKRVL ECLQRSLRVA
781: DSIMDNEQSC ELMVEILNRC LYYFIHGDES ETHISIKYIN GLIELIKTNL KSLKLEDNSA
841: SMITNSISDL HITGENNVKA SSNADDGSVI TDKESNVAIG SDGTYIQLNT LNGSSTLIRG
901: VVATASGSKL LHQLKYIPIH HFRRTCEYIE SQREVDDRFK VIYV