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1.A.9.2.2
The heteromeric serotonin 5HT3A receptor (Hanna et al., 2000). The influences of serotonin on single neurons, neural networks, and cortical circuits in the prefrontal cortex (PFC) of the rat is where the effects of serotonin have been most thoroughly studied (Puig and Gulledge 2011).

Accession Number:P35563
Protein Name:5-hydroxytryptamine 3 receptor aka Htr3a aka 5HT3A
Length:483
Molecular Weight:55428.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate ion

Cross database links:

RefSeq: NP_077370.2   
Entrez Gene ID: 79246   
Pfam: PF02931    PF02932   
KEGG: rno:79246   

Gene Ontology

GO:0030424 C:axon
GO:0030054 C:cell junction
GO:0005737 C:cytoplasm
GO:0005887 C:integral to plasma membrane
GO:0043025 C:neuronal cell body
GO:0045211 C:postsynaptic membrane
GO:0004872 F:receptor activity
GO:0005232 F:serotonin-activated cation-selective channe...
GO:0005249 F:voltage-gated potassium channel activity
GO:0071363 P:cellular response to growth factor stimulus
GO:0006811 P:ion transport
GO:0042220 P:response to cocaine
GO:0007268 P:synaptic transmission

References (4)

[1] “Partial cDNA cloning and NGF regulation of a rat 5-HT3 receptor subunit.”  Isenberg K.E.et.al.   7509203
[2] “Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents.”  Hanna M.C.et.al.   10854267
[3] “Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system.”  Morales M.et.al.   12151552
[4] “A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.”  Kelley S.P.et.al.   12867984

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPLCIPQVLL ALFLSVLIAQ GEGSRRRATQ AHSTTQPALL RLSDHLLANY KKGVRPVRDW 
61:	RKPTLVSIDV IMYAILNVDE KNQVLTTYIW YRQFWTDEFL QWTPEDFDNV TKLSIPTDSI 
121:	WVPDILINEF VDVGKSPSIP YVYVHHQGEV QNYKPLQLVT ACSLDIYNFP FDVQNCSLTF 
181:	TSWLHTIQDI NISLWRTPEE VRSDKSIFIN QGEWELLGVF TKFQEFSIET SNSYAEMKFY 
241:	VVIRRRPLFY AVSLLLPSIF LMVVDIVGFC LPPDSGERVS FKITLLLGYS VFLIIVSDTL 
301:	PATAIGTPLI GVYFVVCMAL LVISLAETIF IVQLVHKQDL QRPVPDWLRH LVLDRIAWLL 
361:	CLGEQPMAHR PPATFQANKT DDCSAMGNHC SHVGSPQDLE KTSRSRDSPL PPPREASLAV 
421:	RGLLQELSSI RHSLEKRDEM REVARDWLRV GYVLDRLLFR IYLLAVLAYS ITLVTLWSIW 
481:	HYS