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5.A.3.5.1
Thiosulfate reductase, PhsABC (Heinzinger et al., 1995) (Clark and Barrett 1987). Menaquinone is the sole electron donor. The endoergonic reduction reaction is driven by the pmf by a reverse loop mechanism (Stoffels et al. 2012). The enzyme can catalyze oxidation of sulfide to sulfite and sulfite to thiosulfate in an exergonic reaction that is pmf-independent (Stoffels et al. 2012). Because the endoergonic reaction is dependent on the pmf, there may be a proton channels in the complex, (possibly subunit C) that allows proton flux into the cell, coupled to the reduction reaction.

Accession Number:P37600
Protein Name:Thiosulfate reductase precursor
Length:758
Molecular Weight:82800.00
Species:Salmonella typhimurium [90371]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate electron

Cross database links:

RefSeq: NP_461010.1   
Entrez Gene ID: 1253586   
Pfam: PF04879    PF00384    PF01568   
BioCyc: MetaCyc:MONOMER-12529    STYP99287:STM2065-MONOMER   
KEGG: stm:STM2065   

Gene Ontology

GO:0051539 F:4 iron, 4 sulfur cluster binding
GO:0009055 F:electron carrier activity
GO:0030151 F:molybdenum ion binding
GO:0016491 F:oxidoreductase activity
GO:0055114 P:oxidation reduction

References (3)

[1] “Sequence analysis of the phs operon in Salmonella typhimurium and the contribution of thiosulfate reduction to anaerobic energy metabolism.”  Heinzinger N.K.et.al.   7751291
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609
[3] “Cloning and characterization of a gene cluster, phsBCDEF, necessary for the production of hydrogen sulfide from thiosulfate by Salmonella typhimurium.”  Alami N.et.al.   7737516

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSISRRSFLQ GVGIGCSACA LGAFPPGALA RNPIAGINGK TTLTPSLCEM CSFRCPIQAQ 
61:	VVNNKTVFIQ GNPSAPQQGT RICARGGSGV SLVNDPQRIV KPMKRTGPRG DGEWQVISWQ 
121:	QAYQEIAAKM NAIKAQHGPE SVAFSSKSGS LSSHLFHLAT AFGSPNTFTH ASTCPAGKAI 
181:	AAKVMMGGDL AMDIANTRYL VSFGHNLYEG IEVADTHELM TAQEKGAKMV SFDPRLSIFS 
241:	SKADEWHAIR PGGDLAVLLA MCHVMIDEQL YDASFVERYT SGFEQLAQAV KETTPEWAAA 
301:	QADVPADVIV RVTRELAACA PHAIVSPGHR ATFSQEEIDM RRMIFTLNVL LGNIEREGGL 
361:	YQKKNASVYN KLAGEKVAPT LAKLNIKNMP KPTAQRIDLV APQFKYIAAG GGVVQSIIDS 
421:	ALTQKPYPIK AWIMSRHNPF QTVTCRSDLV KTVEQLDLVV SCDVYLSESA AYADYLLPEC 
481:	TYLERDEEVS DMSGLHPAYA LRQQVVEPIG EARPSWQIWK ELGEQLGLGQ YYPWQDMQTR 
541:	QLYQLNGDHA LAKELRQKGY LEWGVPLLLR EPESVRQFTA RYPGAIATDS DNTYGEQLRF 
601:	KSPSGKIELY SATLEELLPG YGVPRVRDFA LKKENELYFI QGKVAVHTNG ATQYVPLLSE 
661:	LMWDNAVWVH PQTAQEKGIK TGDEIWLENA TGKEKGKALV TPGIRPDTLF VYMGFGAKAG 
721:	AKTAATTHGI HCGNLLPHVT SPVSGTVVHT AGVTLSRA