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1.N.6.1.1 The mitochondrial inner/outer membrane fusion complex, Fzo/Mgm1/Ugo1. Only the Ugo1 protein is a member of the MC superfamily, and PCD2 is a functional domain required for mitochondrial fusion. It has a single carrier domain (Coonrod et al. 2007).
Accession Number:	P38297
Protein Name:	Transmembrane GTPase FZO1
Length:	855
Molecular Weight:	97808.00
Species:	Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:	2
Location¹ / Topology² / Orientation³:	Mitochondrion outer membrane¹ / Multi-pass membrane protein²
Substrate

DIP:	DIP-5581N
RefSeq:	NP_009738.1
Entrez Gene ID:	852477
Pfam:	PF00350
KEGG:	sce:YBR179C
Gene Ontology GO:0016021 C:integral to membrane GO:0005741 C:mitochondrial outer membrane GO:0005525 F:GTP binding GO:0003924 F:GTPase activity GO:0005515 F:protein binding GO:0008053 P:mitochondrial fusion
References (9) [1] “Complete DNA sequence of yeast chromosome II.” Feldmann H.et.al. 7813418 [2] “Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae.” Rapaport D.et.al. 9685359 [3] “Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p.” Hermann G.J.et.al. 9786948 [4] “Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape.” Sesaki H.et.al. 10562274 [5] “Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion.” Fritz S.et.al. 11266460 [6] “Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane.” Sesaki H.et.al. 12808034 [7] “Global analysis of protein localization in budding yeast.” Huh W.-K.et.al. 14562095 [8] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [9] “Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion.” Sesaki H.et.al. 15087460

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSEGKQQFKD SNKPHKDSTD QDDDAATIVP QTLTYSRNEG HFLGSNFHGV TDDRTTLFDG 
61:	EEGRREDDLL PSLRSSNSKA HLISSQLSQW NYNNNRVLLK RSILKTQAFM DQLQEENNIR 
121:	PIFIAANDER EKLHVLQLNI KLDGQYNTKE KNGFNIEKKA LSKLFHSQIV SVTNHLNALK 
181:	KRVDDVSSKV FITGDVNTGK SALCNSLLKQ RLLPEDQLPC TNVFSEILEA RENDGIEEVH 
241:	AIPLNIAPTL KEAIDMYSIQ NPKTYEIHTL KELPDLVPQN GKYALLKIYI KDDKRPASTS 
301:	LLRNGTVDIS LIDSPGLNMD SLQTAEVMSR QEEIDLVIFV VNAENQLTLS AKEFISLASR 
361:	EKKLMFFVVK KFDKIRDKQR CKELILKQIR DLSPETYKRA ADFVHFVSKN GDELPHYHNE 
421:	NDNEDHGDRK PDDDPYSSSD PDPDFDSLED SLRNFVLKKR SLSKLLPAKT YLSKLLSDII 
481:	MISKSNMKMY SEEEIKINEQ LETLRPEILS ARAKCNDLTT SVDQMAEQTI TMTYNNTKEA 
541:	LLNALDVPLH EYPKYQGLGQ IYDFIFSTEA FIANQIDESI GSSELFAKQK TDLLVKKIYE 
601:	IGKNELGDDF MCERVFRSEL MFRKRKHLIG KRLKVSLSIT DLFAPTWKGF LSYLSWQKPV 
661:	TAPLPDIEGQ TNEGQIGLMK YLGLKNYPLT QYWSRPSLLF TSKIPTLTLY FLGSTKVVGN 
721:	IILNGIKLSS WSSLKKLSVP VIVVGSLLGL TYLIHDLPRA LPMNLSIKYK RKLQELDYIH 
781:	LNAQRTSNEV RDVLRVPTRE ILRSCEIIMD KKQITKKELE NKKESNLLSI KFFQSLYEGT 
841:	VAQKLMVEEI NLDID

1.N.6.1.1
The mitochondrial inner/outer membrane fusion complex, Fzo/Mgm1/Ugo1. Only the Ugo1 protein is a member of the MC superfamily, and PCD2 is a functional domain required for mitochondrial fusion. It has a single carrier domain (Coonrod et al. 2007).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

1.N.6.1.1The mitochondrial inner/outer membrane fusion complex, Fzo/Mgm1/Ugo1. Only the Ugo1 protein is a member of the MC superfamily, and PCD2 is a functional domain required for mitochondrial fusion. It has a single carrier domain (Coonrod et al. 2007).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

1.N.6.1.1
The mitochondrial inner/outer membrane fusion complex, Fzo/Mgm1/Ugo1. Only the Ugo1 protein is a member of the MC superfamily, and PCD2 is a functional domain required for mitochondrial fusion. It has a single carrier domain (Coonrod et al. 2007).