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2.A.108.1.4
High-affinity oxidase-dependent vacuolar Fe2+-Fe3+ uptake transporter (Singh et al. 2006)

Accession Number:P38310
Protein Name:Fth1p
Length:465
Molecular Weight:51495.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate iron(2+), iron(3+)

Cross database links:

DIP: DIP-4165N
RefSeq: NP_009766.1   
Entrez Gene ID: 852506   
Pfam: PF03239   
KEGG: sce:YBR207W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0042802 F:identical protein binding
GO:0005381 F:iron ion transmembrane transporter activity
GO:0006897 P:endocytosis
GO:0006827 P:high-affinity iron ion transport

References (8)

[1] “The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane.”  Urbanowski J.L.et.al.   10608875
[2] “A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes.”  Bussereau F.et.al.   8368014
[3] “Complete DNA sequence of yeast chromosome II.”  Feldmann H.et.al.   7813418
[4] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[6] “Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.”  Chi A.et.al.   17287358
[7] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[8] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAFEDYFSFQ IFFIFLRKSL EIVVIVSILL TIVKQDLSVE DDSPFEGSSS SAGLPSPNTN 
61:	TNADSTTAFL QAGPSDGNAI GTSATAANNK SRPLNVEEEE EIYEYSNELR DQDRESDEHT 
121:	ADNVKLYQKL KIQILAGGAF GLLLCMLIGG AFVSIFYHIG TDLWTLSEHY YEGVLSLVAS 
181:	VIISVMGLFF LRMGKLREKF RVKLASIIYS KDNNLLGNKT QKGVKFSQKY SFFILPFITT 
241:	LREGLEAVYS IGGIGIDQPL SSIPLSMVLA TAISTVFGIF FFRYSSSLSL KICLVVATCF 
301:	LYLIAAGLFS KGVWQLELQD YVNKCNGQDM SEVENGPGSY DISRSVWHVN CCNGEKDGGW 
361:	MIFTAIFGWT NSATVGSVIS YNAYWLVLKY ALKLLMIEGK CGYIPYLPIS WQKKRIMKRL 
421:	SIAKASLDLK HHTSELNSST SEPDSQRRSK DSSVPLIIDS SGSAN