9.B.142.3.14
The glycosyltransferase complex consisting of 8 subunits, all integral membrane proteins. The high resolution 3-dimensional structure has been elucidated (Wild et al. 2018). The catalytic subunit is the STT3 protein of 718 aas and 13 TMSs. The other subunits have 1 - 6 TMSs. The function of the complex is glycosylation of newly synthesized proteins on Asn with Glc3Man9 GlcNac2.
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| Accession Number: | P39007 |
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| Protein Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 |
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| Length: | 718 |
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| Molecular Weight: | 81529.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 13 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGSDRSCVLS VFQTILKLVI FVAIFGAAIS SRLFAVIKFE SIIHEFDPWF NYRATKYLVN
61: NSFYKFLNWF DDRTWYPLGR VTGGTLYPGL MTTSAFIWHA LRNWLGLPID IRNVCVLFAP
121: LFSGVTAWAT YEFTKEIKDA SAGLLAAGFI AIVPGYISRS VAGSYDNEAI AITLLMVTFM
181: FWIKAQKTGS IMHATCAALF YFYMVSAWGG YVFITNLIPL HVFLLILMGR YSSKLYSAYT
241: TWYAIGTVAS MQIPFVGFLP IRSNDHMAAL GVFGLIQIVA FGDFVKGQIS TAKFKVIMMV
301: SLFLILVLGV VGLSALTYMG LIAPWTGRFY SLWDTNYAKI HIPIIASVSE HQPVSWPAFF
361: FDTHFLIWLF PAGVFLLFLD LKDEHVFVIA YSVLCSYFAG VMVRLMLTLT PVICVSAAVA
421: LSKIFDIYLD FKTSDRKYAI KPAALLAKLI VSGSFIFYLY LFVFHSTWVT RTAYSSPSVV
481: LPSQTPDGKL ALIDDFREAY YWLRMNSDED SKVAAWWDYG YQIGGMADRT TLVDNNTWNN
541: THIAIVGKAM ASPEEKSYEI LKEHDVDYVL VIFGGLIGFG GDDINKFLWM IRISEGIWPE
601: EIKERDFYTA EGEYRVDARA SETMRNSLLY KMSYKDFPQL FNGGQATDRV RQQMITPLDV
661: PPLDYFDEVF TSENWMVRIY QLKKDDAQGR TLRDVGELTR SSTKTRRSIK RPELGLRV