TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.15.5
Zinc (Zn2+) porter of E. coli, ZnuABC.  Required for Zn2+ homeostasis and virulence in the close E. coli relative, Salmonella enterica (Ammendola et al., 2007).

Accession Number:P39832
Protein Name:ZnuB aka B1859
Length:261
Molecular Weight:27729.00
Species:Escherichia coli [83333]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate zinc(2+)

Cross database links:

RefSeq: AP_002479.1    NP_416373.1   
Entrez Gene ID: 946372   
Pfam: PF00950   
BioCyc: EcoCyc:ZNUB-MONOMER    ECOL168927:B1859-MONOMER   
KEGG: ecj:JW1848    eco:b1859   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006829 P:zinc ion transport

References (7)

[1] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Structure and regulation of the Escherichia coli ruv operon involved in DNA repair and recombination.”  Shinagawa H.et.al.   2842314
[5] “Intrinsic and extrinsic approaches for detecting genes in a bacterial genome.”  Borodovsky M.et.al.   7984428
[6] “The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli.”  Patzer S.I.et.al.   9680209
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MIELLFPGWL AGIMLACAAG PLGSFVVWRR MSYFGDTLAH ASLLGVAFGL LLDVNPFYAV 
61:	IAVTLLLAGG LVWLEKRPQL AIDTLLGIMA HSALSLGLVV VSLMSNIRVD LMAYLFGDLL 
121:	AVTPEDLISI AIGVVIVVAI LFWQWRNLLS MTISPDLAFV DGVKLQRVKL LLMLVTALTI 
181:	GVAMKFVGAL IITSLLIIPA ATARRFARTP EQMAGVAVLV GMVAVTGGLT FSAVYDTPAG 
241:	PSVVLCAALL FILSMMKKQA S