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2.A.108.1.1
High-affinity oxidase-dependent plasma membrane Fe2+-Fe3+ uptake transporter, Ftr1 of 404 aas and 7 TMSs in a 3 + 3 + 1 TMS arrangement with the N-terminus out and the C-termius in (Severance et al. 2004). There are two REXLE (Arg-Glu-Xaa-Leu-Glu) motifs in transmembrane domains 1 and 4, both essential for transport activity, implying the presence of a 3 TMS repeat ((Severance et al. 2004)). Ftr1 may be a "transceptor", combining transport and receptor functions (Diallinas 2017). Bacterial redox-dependent iron transporters with an emphasis on FtrABCD have been reviewed (Banerjee et al. 2022).

Accession Number:P40088
Protein Name:FTR1 aka Ftr1p aka YER145C
Length:404
Molecular Weight:45722.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate iron(2+), iron(3+)

Cross database links:

DIP: DIP-5376N
RefSeq: NP_011072.1   
Entrez Gene ID: 856888   
Pfam: PF03239   
KEGG: sce:YER145C   

Gene Ontology

GO:0033573 C:high affinity iron permease complex
GO:0016021 C:integral to membrane
GO:0005381 F:iron ion transmembrane transporter activity
GO:0005515 F:protein binding
GO:0006827 P:high-affinity iron ion transport
GO:0033215 P:iron assimilation by reduction and transport

References (4)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[2] “A permease-oxidase complex involved in high-affinity iron uptake in yeast.”  Stearman R.et.al.   8599111
[3] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[4] “Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.”  Gruhler A.et.al.   15665377

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPNKVFNVAV FFVVFRECLE AVIVISVLLS FLKQAIGEHD RALYRKLRIQ VWVGVLLGFI 
61:	ICLAIGAGFI GAYYSLQKDI FGSAEDLWEG IFCMIATIMI SMMGIPMLRM NKMQSKWRVK 
121:	IARSLVEIPH RKRDYFKIGF LSRRYAMFLL PFITVLREGL EAVVFVAGAG ITTQGSHASA 
181:	YPLPVVVGLI CGGLVGYLLY YGASKSSLQI FLILSTSILY LISAGLFSRG AWYFENYRFN 
241:	LASGGDASEG GDGNGSYNIR KAVYHVNCCN PELDNGWDIF NALLGWQNTG YLSSMLCYNI 
301:	YWLVLIIVLS LMIFEERRGH LPFTKNLQLK HLNPGYWIKN KKKQELTEEQ KRQLFAKMEN 
361:	INFNEDGEIN VQENYELPEQ TTSHSSSQNV ATDKEVLHVK ADSL