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| Accession Number: | P40855 |
| Protein Name: | Pex19 aka Peroxin-19 |
| Length: | 299 |
| Molecular Weight: | 32807.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 / Lipid-anchor2 / Cytoplasmic side3 |
| Substrate | |
Cross database links:
| DIP: | DIP-24172N |
|---|---|
| RefSeq: | NP_001124511.1 NP_002848.1 |
| Entrez Gene ID: | 5824 |
| Pfam: | PF04614 |
| OMIM: |
214100 phenotype 600279 gene+phenotype 601539 phenotype |
| KEGG: | hsa:5824 |
Gene Ontology
GO:0031526
C:brush border membrane
GO:0016021
C:integral to membrane
GO:0005634
C:nucleus
GO:0005778
C:peroxisomal membrane
GO:0005515
F:protein binding
GO:0047485
F:protein N-terminus binding
GO:0016557
P:peroxisome membrane biogenesis
GO:0007031
P:peroxisome organization
GO:0006625
P:protein targeting to peroxisome
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References (17)[1] “Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1.” Braun A.et.al. 8076834 [2] “Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein.” Kammerer S.et.al. 9339377 [3] “Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.” Matsuzono Y.et.al. 10051604 [4] “The DNA sequence and biological annotation of human chromosome 1.” Gregory S.G.et.al. 16710414 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.” Gloeckner C.J.et.al. 10777694 [7] “PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.” Sacksteder K.A.et.al. 10704444 [8] “Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.” Sugihara T.et.al. 11259404 [9] “Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.” Fransen M.et.al. 11390669 [10] “Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.” Mayerhofer P.U.et.al. 11883941 [11] “PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.” Fang Y.et.al. 15007061 [12] “PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.” Jones J.M.et.al. 14709540 [13] “Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.” Molina H.et.al. 17287340 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAAAEEGCSV GAEADRELEE LLESALDDFD KAKPSPAPPS TTTAPDASGP QKRSPGDTAK 61: DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDMT 121: SQQEFTSCLK ETLSGLAKNA TDLQNSSMSE EELTKAMEGL GMDEGDGEGN ILPIMQSIMQ 181: NLLSKDVLYP SLKEITEKYP EWLQSHRESL PPEQFEKYQE QHSVMCKICE QFEAETPTDS 241: ETTQKARFEM VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ASGEQCLIM