8.A.217.1.1
The massive protein machine that regulates cell death/apoptosis, BIRC6 is a subunit of 4857 aas with one BIR domain. The complex regulates several caspases (caspase3, caspase7 and caspase9 as well as Omi; see below), BIRC6, SMAC, several IAPs (inhibitors of apoptosis), and ACDR (Apoptosis Cell Death Regulator).
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| Accession Number: | P42574 |
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| Protein Name: | Caspase-3 |
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| Length: | 277 |
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| Molecular Weight: | 31608.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MENTENSVDS KSIKNLEPKI IHGSESMDSG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG
61: MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS
121: HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETDSGVDD
181: DMACHKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC AMLKQYADKL EFMHILTRVN
241: RKVATEFESF SFDATFHAKK QIPCIVSMLT KELYFYH