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2.A.108.1.4
High-affinity oxidase-dependent vacuolar Fe2+-Fe3+ uptake transporter (Singh et al. 2006)

Accession Number:P43561
Protein Name:Fet5p
Length:622
Molecular Weight:70880.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate iron(2+), iron(3+)

Cross database links:

DIP: DIP-6774N
RefSeq: NP_116612.1   
Entrez Gene ID: 850502   
Pfam: PF00394    PF07731    PF07732   
KEGG: sce:YFL041W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005507 F:copper ion binding
GO:0004322 F:ferroxidase activity
GO:0005515 F:protein binding
GO:0006826 P:iron ion transport
GO:0055114 P:oxidation reduction

References (4)

[1] “Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae.”  Murakami Y.et.al.   7670463
[2] “The yeast FET5 gene encodes a FET3-related multicopper oxidase implicated in iron transport.”  Spizzo T.et.al.   9413439
[3] “The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane.”  Urbanowski J.L.et.al.   10608875
[4] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLFYSFVWSV LAASVALAKT HKLNYTASWV TANPDGLHEK RMIGFNGEWP LPDIHVEKGD 
61:	RVELYLTNGF QDNTATSLHF HGLFQNTSLG NQLQMDGPSM VTQCPIVPGQ TYLYNFTVPE 
121:	QVGTFWYHAH MGAQYGDGMR GAFIIHDPEE PFEYDHERVI TLSDHYHENY KTVTKEFLSR 
181:	YNPTGAEPIP QNILFNNTMN VTLDFTPGET YLFRFLNVGL FVSQYIILED HEMSIVEVDG 
241:	VYVKPNFTDS IYLSAGQRMS VLIKAKDKMP TRNYAMMQIM DETMLDVVPP ELQLNQTIQM 
301:	RYGHSLPEAR ALNIEDCDLD RATNDFYLEP LIERDLLAHY DHQIVMDVRM VNLGDGVKYA 
361:	FFNNITYVTP KVPTLTTLLT SGKLASDPRI YGDNINAQLL KHNDIIEVVL NNYDSGRHPF 
421:	HLHGHNFQIV QKSPGFHVDE AYDESEQDEM TVPYNESAPL QPFPERPMVR DTVVLEPSGH 
481:	VVLRFRADNP GVWYFHCHVD WHLQQGLASV FIEAPVLLQE REKLNENYLD ICKAADIPVV 
541:	GNAAGHSNDW FDLKGLPRQP EPLPKGFTTE GYLALIISTI IGVWGLYSIA QYGIGEVIPN 
601:	DEKVYHTLRE ILAENEIEVS RG