5.A.3.4.4
Periplasmic anaerobic methionine oxide reductase 2, TorYZ (also called MtsZ/BisC), both with an N-terminal TMS. It supports survival of Haemophilus influenzae in an in vivo model of infection (Dhouib et al. 2016). It is an S- and N-oxide reductase with a stereospecificity for
S-sulfoxides. The enzyme converts two physiologically relevant
sulfoxides, biotin sulfoxide (BSO) and methionine sulfoxide (MetSO), with the
kinetic parameters suggesting that MetSO is the natural substrate of
this enzyme (Dhouib et al. 2016).
|
| Accession Number: | P44799 |
|---|
| Protein Name: | Cytochrome c-type protein TorY |
|---|
| Length: | 368 |
|---|
| Molecular Weight: | 41145.00 |
|---|
| Species: | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [71421] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Single-pass type II membrane protein2 |
|---|
| Substrate |
|
|---|
1: MAMSKMKKIV TALCLVGVGV GALWGSQWIM HKTSTPEFCA SCHSMSYPQQ EWEGSSHFAN
61: AKGVRAQCSD CHIPKEGWHY VKAKFIALKD LWYEAQGKIE NKEKYEAHRA EMAQRVWKDM
121: KANDSETCRS CHSFDAMELS KQTKLAKQTH TEAQTNGQTC IDCHKGIVHF LPEVHGDQNT
181: QKSSAVQGGT LSDGSAIFAT EMVKATNDKG NEVRLMPYAE LMQWKVDGDQ IQGTLHGWQQ
241: VGAEAVVYQE LGKRITLALM DEDARNHVQV LKIVHDAVTD SDWKEISVAV NVAKEKMTSD
301: LTTLNQYGNQ LNQTQCSGCH AAIGADHYTA NQWIGVVNSM KDRTSMKKDE VRALTIYLQR
361: NAKDMAKQ