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3.A.1.12.2 Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate). The system has been reconstituted in nanodiscs and shows substrate-dependent ionic stringth-gated gating and energy coupling dependent on anionic lipids (Karasawa et al. 2013).
Accession Number:	P46920
Protein Name:	OPAA aka OpuAA
Length:	418
Molecular Weight:	46468.00
Species:	Bacillus subtilis [1423]
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Peripheral membrane protein²
Substrate	glycine betaine, (carboxymethyl)(dimethyl)sulfonium, S,S-dimethyl-beta-propiothetin

RefSeq:	NP_388180.2
Entrez Gene ID:	938362
Pfam:	PF00005 PF00571
KEGG:	bsu:BSU02980
Gene Ontology GO:0016020 C:membrane GO:0015171 F:amino acid transmembrane transporter activity GO:0005524 F:ATP binding GO:0015418 F:quaternary-ammonium-compound-transporting A... GO:0006865 P:amino acid transport
References (4) [1] “OpuA, an osmotically regulated binding protein-dependent transport system for the osmoprotectant glycine betaine in Bacillus subtilis.” Kempf B.et.al. 7622480 [2] “The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes.” Yamane K.et.al. 8969502 [3] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.” Kunst F.et.al. 9384377 [4] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.” Barbe V.et.al. 19383706

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSVDEKPIKI KVEKVSKIFG KQTKKAVQML ANGKTKKEIL KATGSTVGVN QADFEVYDGE 
61:	IFVIMGLSGS GKSTLVRMLN RLIEPTAGNI YIDGDMITNM SKDQLREVRR KKISMVFQKF 
121:	ALFPHRTILE NTEYGLELQG VDKQERQQKA LESLKLVGLE GFEHQYPDQL SGGMQQRVGL 
181:	ARALTNDPDI LLMDEAFSAL DPLIRKDMQD ELLDLHDNVG KTIIFITHDL DEALRIGDRI 
241:	VLMKDGNIVQ IGTPEEILMN PSNEYVEKFV EDVDLSKVLT AGHIMKRAET VRIDKGPRVA 
301:	LTLMKNLGIS SIYAVDKQKK LLGVIYASDA KKAAESDLSL QDILNTEFTT VPENTYLTEI 
361:	FDVVSDANIP IAVVDEKQRM KGIVVRGALI GALAGNNEYI NAEGTNEQTQ DPSAQEVK

3.A.1.12.2
Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate). The system has been reconstituted in nanodiscs and shows substrate-dependent ionic stringth-gated gating and energy coupling dependent on anionic lipids (Karasawa et al. 2013).

Cross database links:

Gene Ontology

References (4)

External Searches:

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3.A.1.12.2Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate). The system has been reconstituted in nanodiscs and shows substrate-dependent ionic stringth-gated gating and energy coupling dependent on anionic lipids (Karasawa et al. 2013).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

3.A.1.12.2
Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate). The system has been reconstituted in nanodiscs and shows substrate-dependent ionic stringth-gated gating and energy coupling dependent on anionic lipids (Karasawa et al. 2013).