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1.A.9.1.2
The nicotinic acetylcholine activated cation selective channel precursor, Acr-2 or Acr-3/Unc-38 (both β and α-type chains are required for activity; levamisole-gated; activity reduced by antagonists mecamylamine and d-tubocurarine) (Squire et al., 1995; Baylis et al., 1997). nAChR and TRPC channel proteins (1.A.4) mediate nicotine addiction in many animals from humans to worms (Feng et al., 2006). Functions at synapses in the nervous system and at neuromuscular junctions (Towers et al. 2006). Neonicottinoides affect worm behavior and development (Kudelska et al. 2017). C. elegans has a large number of nAcChR genes, only some of which are retained in parasitic nematodes (Holden-Dye et al. 2013). RIC-3 is an nAcChR chaparone (Treinin 2008).

Accession Number:P48182
Protein Name:Acetylcholine receptor subunit beta-type acr-2
Length:575
Molecular Weight:65595.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate cation

Cross database links:

RefSeq: NP_509128.1   
Entrez Gene ID: 180936   
Pfam: PF02931    PF02932   
KEGG: cel:K11G12.2   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0045211 C:postsynaptic membrane
GO:0004889 F:nicotinic acetylcholine-activated cation-se...
GO:0004872 F:receptor activity
GO:0006811 P:ion transport

References (2)

[1] “Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2).”  Squire M.D.et.al.   8581398
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKKTVKILLI LITVFLKVHC NGGHDDEAAD FLSHTNIDDP NNSSDPNKNS DQGDTMGEDE 
61:	DRLVIDLFRE YNFLIRPVKN VSSPPVVVDF GVAMILLINV DEKNQILQTN VWLTMKWNDF 
121:	QLAWNPAEYG NISNLHVPSD RVWLPDIVLF NNADGNYEVS FKSNVFVDHH GDVTWVPPAM 
181:	FKSSCRIDVE WFPFDEQCCT LVFGSWTYNS EEVRLHWYNN IQAVQLHDYS YSGIWDVIDV 
241:	PGQLVHKPDL KENKMVFNVV IRRKTLFYTV ILIIPTVLMA FLSVMAFYLP VDSGEKVSLT 
301:	ISLLLALVVF LLLVSKILPP TSNIPLMGKY LLLAFVLNIT AVVGTVVIVN IYFRSALSHK 
361:	MPTWVRKVFL EFLPHLLVMK RPERIPIFNG YFVEEYCASE IFDASLVMPS MTATMLPFLQ 
421:	VTTNLKAASS TSSGQSSEHH ENCSKWKKRL SIRMSKRRAP RARLDDDSED IIDDTNGNHV 
481:	DSLQEKISKE MKTTVEAIAY IAEHMKREMS LKKMRDDWKY VAMVLDRLIL LIFFGVTLGG 
541:	TLGIICSAPH VFDFVDQEAI ISKLNAKYLP SDMYS