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|---|---|
| Accession Number: | P52298 |
| Protein Name: | Nuclear cap-binding protein subunit 2 |
| Length: | 156 |
| Molecular Weight: | 18001.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Nucleus1 |
| Substrate | small nuclear RNA |
Cross database links:
| DIP: | DIP-33246N |
|---|---|
| Entrez Gene ID: | 22916 |
| Pfam: | PF00076 |
| KEGG: | hsa:22916 |
Gene Ontology
GO:0005829
C:cytosol
GO:0005845
C:mRNA cap binding complex
GO:0005654
C:nucleoplasm
GO:0000166
F:nucleotide binding
GO:0005515
F:protein binding
GO:0000340
F:RNA 7-methylguanosine cap binding
GO:0031047
P:gene silencing by RNA
GO:0008334
P:histone mRNA metabolic process
GO:0031124
P:mRNA 3'-end processing
GO:0006370
P:mRNA capping
GO:0006406
P:mRNA export from nucleus
GO:0034660
P:ncRNA metabolic process
GO:0000184
P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0046833
P:positive regulation of RNA export from nucleus
GO:0050434
P:positive regulation of viral transcription
GO:0006446
P:regulation of translational initiation
GO:0006408
P:snRNA export from nucleus
GO:0000387
P:spliceosomal snRNP assembly
GO:0006369
P:termination of RNA polymerase II transcription
GO:0006368
P:transcription elongation from RNA polymerase II promoter
GO:0016032
P:viral reproduction
| |
References (20)[1] “A cap-binding protein complex mediating U snRNA export.” Izaurralde E.et.al. 7651522 [2] “Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein.” Kataoka N.et.al. 7478990 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export.” Visa N.et.al. 8601613 [6] “Interaction between the human nuclear cap-binding protein complex and hnRNP F.” Gamberi C.et.al. 9111328 [7] “Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20.” Ishigaki Y.et.al. 11551508 [8] “The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.” Lejeune F.et.al. 12093754 [9] “eIF4G is required for the pioneer round of translation in mammalian cells.” Lejeune F.et.al. 15361857 [10] “Human mRNA export machinery recruited to the 5' end of mRNA.” Cheng H.et.al. 17190602 [11] “The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export.” Nojima T.et.al. 17363367 [12] “Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA.” Matsuda D.et.al. 17873884 [13] “ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.” Matsuoka S.et.al. 17525332 [14] “NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.” Woeller C.F.et.al. 18369367 [15] “Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.” Gruber J.J.et.al. 19632182 [16] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.” Choudhary C.et.al. 19608861 | |
| Structure: | |
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| FASTA formatted sequence |
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1: MSGGLLKALR SDSYVELSQY RDQHFRGDNE EQEKLLKKSC TLYVGNLSFY TTEEQIYELF 61: SKSGDIKKII MGLDKMKKTA CGFCFVEYYS RADAENAMRY INGTRLDDRI IRTDWDAGFK 121: EGRQYGRGRS GGQVRDEYRQ DYDAGRGGYG KLAQNQ