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3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P53266
Protein Name:Cytochrome oxidase assembly protein SHY1
Length:389
Molecular Weight:45056.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 853009   
Pfam: PF02104   
KEGG: sce:YGR112W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0051082 F:unfolded protein binding
GO:0009060 P:aerobic respiration
GO:0033617 P:mitochondrial respiratory chain complex IV assembly

References (10)

[1] “The sequence of a 23.4 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3 element and 11 new open reading frames.”  Hansen M.et.al.   8905931
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.”  Tettelin H.et.al.   9169869
[3] “SHY1, the yeast homolog of the mammalian SURF-1 gene, encodes a mitochondrial protein required for respiration.”  Mashkevich G.et.al.   9162072
[4] “Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome.”  Barrientos A.et.al.   11782424
[5] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[7] “The proteome of Saccharomyces cerevisiae mitochondria.”  Sickmann A.et.al.   14576278
[8] “Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.”  Pierrel F.et.al.   17882260
[9] “Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.”  Mick D.U.et.al.   17882259
[10] “Coa2 is an assembly factor for yeast cytochrome C oxidase biogenesis that facilitates the maturation of cox1.”  Pierrel F.et.al.   18541668

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FASTA formatted sequence 
1:	MSLLGARSTY RWFSIAASIP TKNAIGKSTY LLASRNQQYR GIITSTVDWK PIKTGKSPND 
61:	DSRRERSFGK KIVLGLMFAM PIISFYLGTW QVRRLKWKTK LIAACETKLT YEPIPLPKSF 
121:	TPDMCEDWEY RKVILTGHFL HNEEMFVGPR KKNGEKGYFL FTPFIRDDTG EKVLIERGWI 
181:	SEEKVAPDSR NLHHLSLPQE EHLKVVCLVR PPKKRGSLQW AKKDPNSRLW QVPDIYDMAR 
241:	SSGCTPIQFQ ALYDMKDHPI IEEHTRNEAS QNNSTSSLWK FWKREPTTAV NGTQAVDNNT 
301:	SKPRSRQEMP TDQTIEFDER QFIKAGVPIG RKPTIDLKNN HLQYLVTWYG LSFLSTIFLI 
361:	VALRKAKRGG VVSQDQLMKE KLKHSRKYM