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9.A.50.1.1 The tRNA nuclear export machinery, t-Exporter. Includes UTP8, a tRNA-binding protein, Los1 and Msn5/ two tRNA export receptors (Strub et al., 2007). Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5 has been reported (Fung et al. 2025).
Accession Number:	P53276
Protein Name:	t-UTP8
Length:	713
Molecular Weight:	80191.00
Species:	Saccharomyces cerevisiae [4932]
Location¹ / Topology² / Orientation³:	Nucleus¹
Substrate	protein, transfer RNA

Structure:
DIP:	DIP-6747N
RefSeq:	NP_011644.1
Entrez Gene ID:	853029
Pfam:	PF10395
KEGG:	sce:YGR128C
Gene Ontology GO:0033553 C:rDNA heterochromatin GO:0032040 C:small-subunit processome GO:0034455 C:t-UTP complex GO:0005515 F:protein binding GO:0030515 F:snoRNA binding GO:0000049 F:tRNA binding GO:0000462 P:maturation of SSU-rRNA from tricistronic rR... GO:0045943 P:positive regulation of transcription from R... GO:0006350 P:transcription GO:0006409 P:tRNA export from nucleus
References (7) [1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.” Tettelin H.et.al. 9169869 [2] “A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.” Dragon F.et.al. 12068309 [3] “Utp8p is an essential intranuclear component of the nuclear tRNA export machinery of Saccharomyces cerevisiae.” Steiner-Mosonyi M.et.al. 12794079 [4] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [5] “RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components.” Gallagher J.E.G.et.al. 15489292 [6] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.” Smolka M.B.et.al. 17563356 [7] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.” Albuquerque C.P.et.al. 18407956
5WLC 6KE6 6LQP 6LQQ 6LQR 6LQS 6LQU 6LQV 6ND4 [...more]

UniProt (Universal Protein Resource)
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FASTA formatted sequence

1:	MPSLSQPFRL ATLPKIASLS NFSLQADYVQ VADGTFNEST NNITLGISGS SISQYIINPT 
61:	PKLTFDYPIP STNIITACNA EKGQANIDGN IEASTDDEAN NEKTINTQKK RNVEIWAFGL 
121:	MVNKGNYTLN VITKALEDTT DTSNDHLSES DIDNKAYTGS DEFLSQYKIK AKAKVMSIKI 
181:	DTKNSLVIAI LQNGLIEIFD FKLTLLHSFD ISYDNLKYAK WFTENGTEYV FVLCPLQDDK 
241:	VCYKLLELTD CGSGESSPIK ELSSTIIEGF SFENSKLCYQ FGKLYKLNQG KIYIYSLPHC 
301:	QLQQVIEFPM VDKLSPGDDL ISFQPVSVNR VLLTVNNVIY LLDLLHCSTL SQRELTHVKT 
361:	FQLLKSAVIN SEKSHNSKTI AIGISTKNGP NPTSSLEIIN IDVGTNTLKD SLGKSFQVGN 
421:	NDSSVILKPL FDDKDINDKR VKCNDVSGDS SVPVLHCNEV IEKLSALQDN DITSFDDIFF 
481:	KELKIKEEHY TEKDRYISDP GFLNKVLDLI FGKFSGNDYP KTLTFLLTHP LFPLSRTRNL 
541:	LSLLRDQPRL FKQAIVTCPN LPLNELLEEL FSIRNRELLL DISFRILQDF TRDSIKQEMK 
601:	KLSKLDVQNF IEFITSGGED SSPECFNPSQ STQLFQLLSL VLDSIGLFSL EGALLENLTL 
661:	YIDKQVEIAE RNTELWNLID TKGFQHGFAS STFDNGTSQK RALPTYTMEY LDI

9.A.50.1.1
The tRNA nuclear export machinery, t-Exporter. Includes UTP8, a tRNA-binding protein, Los1 and Msn5/ two tRNA export receptors (Strub et al., 2007). Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5 has been reported (Fung et al. 2025).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

9.A.50.1.1The tRNA nuclear export machinery, t-Exporter. Includes UTP8, a tRNA-binding protein, Los1 and Msn5/ two tRNA export receptors (Strub et al., 2007). Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5 has been reported (Fung et al. 2025).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

9.A.50.1.1
The tRNA nuclear export machinery, t-Exporter. Includes UTP8, a tRNA-binding protein, Los1 and Msn5/ two tRNA export receptors (Strub et al., 2007). Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5 has been reported (Fung et al. 2025).