| |
|---|---|
| Accession Number: | P55072 |
| Protein Name: | p97 ATPase aka TER ATPase |
| Length: | 806 |
| Molecular Weight: | 89322.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 |
| Substrate | |
Cross database links:
| DIP: | DIP-33543N |
|---|---|
| RefSeq: | NP_009057.1 |
| Entrez Gene ID: | 7415 |
| Pfam: | PF00004 PF02933 PF02359 PF09336 |
| OMIM: |
167320 phenotype 601023 gene |
| KEGG: | hsa:7415 |
Gene Ontology
GO:0005829
C:cytosol
GO:0005783
C:endoplasmic reticulum
GO:0005792
C:microsome
GO:0005634
C:nucleus
GO:0000502
C:proteasome complex
GO:0005524
F:ATP binding
GO:0016887
F:ATPase activity
GO:0008289
F:lipid binding
GO:0031593
F:polyubiquitin binding
GO:0019904
F:protein domain specific binding
GO:0019903
F:protein phosphatase binding
GO:0006919
P:activation of caspase activity
GO:0006302
P:double-strand break repair
GO:0030968
P:endoplasmic reticulum unfolded protein resp...
GO:0030433
P:ER-associated protein catabolic process
GO:0032436
P:positive regulation of proteasomal ubiquiti...
GO:0016567
P:protein ubiquitination
GO:0030970
P:retrograde protein transport, ER to cytosol
| |
References (27)[1] “Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.” Hu R.-M.et.al. 10931946 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “DNA sequence and analysis of human chromosome 9.” Humphray S.J.et.al. 15164053 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.” Gevaert K.et.al. 12665801 [6] “A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.” McNeill H.et.al. 15362974 [7] “Physical and functional interaction between dorfin and valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.” Ishigaki S.et.al. 15456787 [8] “A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.” Ye Y.et.al. 15215856 [9] “The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway.” Schulze A.et.al. 16289116 [10] “Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC).” Amanchy R.et.al. 16212419 [11] “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.” Rush J.et.al. 15592455 [12] “Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane.” Ye Y.et.al. 16186510 [13] “Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.” Lilley B.N.et.al. 16186509 [14] “Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin.” Huang Y.et.al. 16513638 [15] “Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.” Oda Y.et.al. 16449189 [16] “Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation.” Liang J.et.al. 16968747 [17] “ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.” Matsuoka S.et.al. 17525332 [18] “Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.” Imami K.et.al. 18187866 [19] “Ubxd1 is a novel co-factor of the human p97 ATPase.” Madsen L.et.al. 18656546 [20] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 [21] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [22] “The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.” Ernst R.et.al. 19818707 [23] “Large-scale proteomics analysis of the human kinome.” Oppermann F.S.et.al. 19369195 [24] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 [25] “Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein.” Watts G.D.J.et.al. 15034582 | |
| Structure: | |
| [...more] | |
External Searches:
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| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MASGADSKGD DLSTAILKQK NRPNRLIVDE AINEDNSVVS LSQPKMDELQ LFRGDTVLLK 61: GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI SIQPCPDVKY GKRIHVLPID 121: DTVEGITGNL FEVYLKPYFL EAYRPIRKGD IFLVRGGMRA VEFKVVETDP SPYCIVAPDT 181: VIHCEGEPIK REDEEESLNE VGYDDIGGCR KQLAQIKEMV ELPLRHPALF KAIGVKPPRG 241: ILLYGPPGTG KTLIARAVAN ETGAFFFLIN GPEIMSKLAG ESESNLRKAF EEAEKNAPAI 301: IFIDELDAIA PKREKTHGEV ERRIVSQLLT LMDGLKQRAH VIVMAATNRP NSIDPALRRF 361: GRFDREVDIG IPDATGRLEI LQIHTKNMKL ADDVDLEQVA NETHGHVGAD LAALCSEAAL 421: QAIRKKMDLI DLEDETIDAE VMNSLAVTMD DFRWALSQSN PSALRETVVE VPQVTWEDIG 481: GLEDVKRELQ ELVQYPVEHP DKFLKFGMTP SKGVLFYGPP GCGKTLLAKA IANECQANFI 541: SIKGPELLTM WFGESEANVR EIFDKARQAA PCVLFFDELD SIAKARGGNI GDGGGAADRV 601: INQILTEMDG MSTKKNVFII GATNRPDIID PAILRPGRLD QLIYIPLPDE KSRVAILKAN 661: LRKSPVAKDV DLEFLAKMTN GFSGADLTEI CQRACKLAIR ESIESEIRRE RERQTNPSAM 721: EVEEDDPVPE IRRDHFEEAM RFARRSVSDN DIRKYEMFAQ TLQQSRGFGS FRFPSGNQGG 781: AGPSQGSGGG TGGSVYTEDN DDDLYG