8.A.217.1.1
The massive protein machine that regulates cell death/apoptosis, BIRC6 is a subunit of 4857 aas with one BIR domain. The complex regulates several caspases (caspase3, caspase7 and caspase9 as well as Omi; see below), BIRC6, SMAC, several IAPs (inhibitors of apoptosis), and ACDR (Apoptosis Cell Death Regulator).
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| Accession Number: | P55210 |
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| Protein Name: | Caspase-7 |
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| Length: | 303 |
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| Molecular Weight: | 34277.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT TRDRVPTYQY
61: NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC FRSLGFDVIV YNDCSCAKMQ
121: DLLKKASEED HTNAACFACI LLSHGEENVI YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL
181: FFIQACRGTE LDDGIQADSG PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRSPGRGSW
241: FVQALCSILE EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP HFHEKKQIPC VVSMLTKELY
301: FSQ