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9.A.17.1.2
The Pex3/Pex16/Pex19 peroxisomal protein importer is for insertion of integral membranes into the peroxisomal and ER membranes. Monotopic hairpin proteins are inserted into ER membranes. These either remain in the ER as resident ER membrane proteins, or are pinched off from the ER as components of new lipid droplets (Zimmermann et al. 2021).

Accession Number:P56589
Protein Name:Pex3 aka Peroxin-3
Length:373
Molecular Weight:42140.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Peroxisome membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

RefSeq: NP_003621.1   
Entrez Gene ID: 8504   
Pfam: PF04882   
OMIM: 214100  phenotype
601539  phenotype
603164  gene+phenotype
KEGG: hsa:8504   

Gene Ontology

GO:0005779 C:integral to peroxisomal membrane
GO:0005515 F:protein binding
GO:0045046 P:protein import into peroxisome membrane

References (10)

[1] “Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p.”  Kammerer S.et.al.   9657383
[2] “Identification and characterization of the human peroxin PEX3.”  Soukupova M.et.al.   10430017
[3] “The human PEX3 gene encoding a peroxisomal assembly protein: genomic organization, positional mapping, and mutation analysis in candidate phenotypes.”  Muntau A.C.et.al.   10679269
[4] “The peroxin pex3p initiates membrane assembly in peroxisome biogenesis.”  Ghaedi K.et.al.   10848631
[5] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.”  Sacksteder K.A.et.al.   10704444
[8] “Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.”  Fransen M.et.al.   11390669
[9] “PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.”  Fang Y.et.al.   15007061
[10] “Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G.”  Muntau A.C.et.al.   10958759
Structure:
3AJB   3MK4     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLRSVWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA QARRQYHFES 
61:	NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKNRPSNK LEIWEDLKII SFTRSTVAVY 
121:	STCMLVVLLR VQLNIIGGYI YLDNAAVGKN GTTILAPPDV QQQYLSSIQH LLGDGLTELI 
181:	TVIKQAVQKV LGSVSLKHSL SLLDLEQKLK EIRNLVEQHK SSSWINKDGS KPLLCHYMMP 
241:	DEETPLAVQA CGLSPRDITT IKLLNETRDM LESPDFSTVL NTCLNRGFSR LLDNMAEFFR 
301:	PTEQDLQHGN SMNSLSSVSL PLAKIIPIVN GQIHSVCSET PSHFVQDLLT MEQVKDFAAN 
361:	VYEAFSTPQQ LEK