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3.A.2.2.5
H -translocating V-type ATPase (Dettmer et al., 2006). The mung bean (Phaseolus aureus) subunits a and c (c' and c") alone catalyzes passive channel-mediated proton flux, but the a,c,d complex does not (Ouyang et al., 2008).  A 4 TMS c-subunit of Tamarix hispida (onion), almost identical to the c-subunit of the A. thaliana homologue, plays a stress tolerance role in response to salt, drought, UV, oxidation, heat, cold, and heavy metals (Gao et al. 2011). The VHA-H subunit is up-regluated upon high salt stress conditions (Yang et al. 2018). The VHAc`1 protein seems to play an important role in plant stress tolerance (Wang et al. 2020).

Accession Number:P59227
Protein Name:V-type proton ATPase 16 kDa proteolipid subunit c1/c3/c5
Length:164
Molecular Weight:16572.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

Entrez Gene ID: 816150    829624    830047   
Pfam: PF00137   
KEGG: ath:AT2G16510    ath:AT4G34720    ath:AT4G38920   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0033179 C:proton-transporting V-type ATPase, V0 domain
GO:0005774 C:vacuolar membrane
GO:0015078 F:hydrogen ion transmembrane transporter activity
GO:0005515 F:protein binding
GO:0015986 P:ATP synthesis coupled proton transport

References (5)

[1] “Several distinct genes encode nearly identical to 16 kDa proteolipids of the vacuolar H(+)-ATPase from Arabidopsis thaliana.”  Perera I.Y.et.al.   7579175
[2] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[3] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “A simple nomenclature for a complex proton pump: VHA genes encode the vacuolar H(+)-ATPase.”  Sze H.et.al.   11950611

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSTFSGDETA PFFGFLGAAA ALVFSCMGAA YGTAKSGVGV ASMGVMRPEL VMKSIVPVVM 
61:	AGVLGIYGLI IAVIISTGIN PKAKSYYLFD GYAHLSSGLA CGLAGLSAGM AIGIVGDAGV 
121:	RANAQQPKLF VGMILILIFA EALALYGLIV GIILSSRAGQ SRAE