TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.27.5
The Mce/Yrb/Mlk (Mammalian cell entry) ABC-type putative steroid uptake transporter (involved in several aspects of mycobacterial pathogenesis) (Mohn et al., 2008; Joshi et al., 2006).

Accession Number:P63357
Protein Name:Probable ribonucleotide transport ATP-binding protein mkl
Length:359
Molecular Weight:39394.00
Species:mycobacterium tuberculosis [1773]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate steroids

Cross database links:

RefSeq: NP_215169.1    NP_335095.1   
Entrez Gene ID: 888081    925967   
Pfam: PF00005   
KEGG: mtc:MT0684    mtu:Rv0655   

Gene Ontology

GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0006810 P:transport

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MRYSDSYHTT GRWQPRASTE GFPMGVSIEV NGLTKSFGSS RIWEDVTLTI PAGEVSVLLG 
61:	PSGTGKSVFL KSLIGLLRPE RGSIIIDGTD IIECSAKELY EIRTLFGVLF QDGALFGSMN 
121:	LYDNTAFPLR EHTKKKESEI RDIVMEKLAL VGLGGDEKKF PGEISGGMRK RAGLARALVL 
181:	DPQIILCDEP DSGLDPVRTA YLSQLIMDIN AQIDATILIV THNINIARTV PDNMGMLFRK 
241:	HLVMFGPREV LLTSDEPVVR QFLNGRRIGP IGMSEEKDEA TMAEEQALLD AGHHAGGVEE 
301:	IEGVPPQISA TPGMPERKAV ARRQARVREM LHTLPKKAQA AILDDLEGTH KYAVHEIGQ