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3.A.24.1.1
The RD1 (ESX-1) protein secretion complex (Type VII protein secretion system, T7SS).  EccA1 may be a secreted protein while ECCB1 - E1 may comprise the system (Houben et al. 2012).  This system (ESX-1) is present in the avirulent species, Mycobacterium smegmatis, where it is involved in conjugation (Coros et al. 2008).  ESX-1 uses the ESX-1-specific chaparone protein, EspG to interact with the secreted PE/PPE complex, while a homologous EspG specific for ESX-5 functions with the PE/PPE complex secreted by ESX-5.  Thus, EspG proteins may be system-specific chaparones for T7SSs (Daleke et al. 2012).  The main secreted virulence protein complex is a heterodimer: EsxA(ESAT-6)/EsxB(CFP-10) (Rosenberger et al. 2012). EccB, a periplasmic homoheximer with the ATP-binding active site shared by two adjacent subunits, may act as the energy provider in the transport of T7SS virulence factors and may be involved in the formation of a channel across the mycomembrane (Zhang et al. 2015). ESX-1 functions in resistance to and evasion of host responses.  It induces phagosomal rupture which releases bacteria into the cytosol of the host phagocytes (Gröschel et al. 2016). ESX-1 secrete EsxA and EsxB, which form a heterodimer, seem to have differing functions as EsxA can disrupt lipid bilayers (RBC and artificial membranes.  Thus EsxA may form pores as a prelude to membrane disruption (Gröschel et al. 2016).

Accession Number:P65087
Protein Name:Rv3615c (MT3717)
Length:103
Molecular Weight:10795.00
Species:Mycobacterium tuberculosis [1773]
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

RefSeq: NP_218132.1    NP_338262.1   
Entrez Gene ID: 885770    926517   
KEGG: mtc:MT3717    mtu:Rv3615c   

References (5)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis.”  MacGurn J.A.et.al.   16135231
[4] “Secreted transcription factor controls Mycobacterium tuberculosis virulence.”  Raghavan S.et.al.   18685700
[5] “ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.”  DiGiuseppe Champion P.A.et.al.   19682254

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTENLTVQPE RLGVLASHHD NAAVDASSGV EAAAGLGESV AITHGPYCSQ FNDTLNVYLT 
61:	AHNALGSSLH TAGVDLAKSL RIAAKIYSEA DEAWRKAIDG LFT