TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.B.70.1.1
The putative SpoIIIA-SpoIIQ exporter.  SpoIIIAE and SpoIIQ form a transenvelop channel (resembling in function a gap junction in animals) that allows the passage of small molecules and proteins from the mother cell to the forespore (Rodrigues et al. 2016). The SpoIIIA-SpoIIQ complex appears to be a hybrid composed of different parts from well-defined specialized secretion systems (Morlot and Rodrigues 2018).

Accession Number:P71044
Protein Name:Stage II sporulation protein Q
Length:283
Molecular Weight:31113.00
Species:Bacillus subtilis [1423]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Forespore membrane1 / Single-pass membrane protein2
Substrate protein

Cross database links:

RefSeq: NP_391536.1   
Entrez Gene ID: 936951   
Pfam: PF01551   
BioCyc: SUBTI:BSU36550-MONOMER   
KEGG: bsu:BSU36550   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0004222 F:metalloendopeptidase activity
GO:0006508 P:proteolysis
GO:0030435 P:sporulation resulting in formation of a cel...

References (14)

[1] “The Bacillus subtilis ureABC operon.”  Cruz-Ramos H.et.al.   9150240
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “SpoIIQ, a forespore-expressed gene required for engulfment in Bacillus subtilis.”  Londono-Vallejo J.A.et.al.   9140963
[4] “A dispensable role for forespore-specific gene expression in engulfment of the forespore during sporulation of Bacillus subtilis.”  Sun Y.-L.et.al.   10781563
[5] “Septal localization of forespore membrane proteins during engulfment in Bacillus subtilis.”  Rubio A.et.al.   15044948
[6] “Zipper-like interaction between proteins in adjacent daughter cells mediates protein localization.”  Blaylock B.et.al.   15574594
[7] “Developmental commitment in a bacterium.”  Dworkin J.et.al.   15882622
[8] “Subcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum.”  Doan T.et.al.   15752199
[9] “Engulfment-regulated proteolysis of SpoIIQ: evidence that dual checkpoints control sigma activity.”  Jiang X.et.al.   16164552
[10] “Forespore engulfment mediated by a ratchet-like mechanism.”  Broder D.H.et.al.   16959571
[11] “Dual localization pathways for the engulfment proteins during Bacillus subtilis sporulation.”  Aung S.et.al.   17824930
[12] “SpoIIQ anchors membrane proteins on both sides of the sporulation septum in Bacillus subtilis.”  Campo N.et.al.   18077456
[13] “A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels.”  Camp A.H.et.al.   18485064
[14] “A channel connecting the mother cell and forespore during bacterial endospore formation.”  Meisner J.et.al.   18812514
Structure:
3TUF   3UZ0     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MREEEKKTSQ VKKLQQFFRK RWVFPAIYLV SAAVILTAVL WYQSVSNDEV KDQLADNGGN 
61:	SAYDNNDDAV EVGKSMENVA MPVVDSENVS VVKKFYETDA AKEEKEAALV TYNNTYSLSK 
121:	GIDLAEKDGK DFDVSASLSG TVVKAEKDPV LGYVVEVEHA DGLSTVYQSL SEVSVEQGDK 
181:	VKQNQVIGKS GKNLYSEDSG NHVHFEIRKD GVAMNPLNFM DKPVSSIEKA ATQETEESIQ 
241:	QSSEKKDGST EKGTEEKSGE KKDDSTDKSG SKESSTTEDT EQS