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3.A.1.2.8 Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)
Accession Number:	P76142
Protein Name:	LsrB(R)
Length:	340
Molecular Weight:	36685.00
Species:	Escherichia coli [83333]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Periplasm¹
Substrate

RefSeq:	AP_002137.1 NP_416033.1
Entrez Gene ID:	945418
BioCyc:	EcoCyc:YNEA-MONOMER ECOL168927:B1516-MONOMER
KEGG:	ecj:JW1509 eco:b1516
Gene Ontology GO:0042597 C:periplasmic space
References (4) [1] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [3] “Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli.” Xavier K.B.et.al. 15601708 [4] “Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli.” Wang L.et.al. 15743955

BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
CDD Search (Conserved Domain Database)
Search COGs (Clusters of Orthologous Groups of proteins)
Secondary Structure Search

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MTLHRFKKIA LLSALGIAAI SMNVQAAERI AFIPKLVGVG FFTSGGNGAQ QAGKELGVDV 
61:	TYDGPTEPSV SGQVQLINNF VNQGYNAIIV SAVSPDGLCP ALKRAMQRGV RVLTWDSDTK 
121:	PECRSYYINQ GTPAQLGGML VDMAARQVNK DKAKVAFFYS SPTVTDQNQW VKEAKAKIAK 
181:	EHPGWEIVTT QFGYNDATKS LQTAEGILKA YSDLDAIIAP DANALPAAAQ AAENLKNDKV 
241:	AIVGFSTPNV MRPYVERGTV KEFGLWDVVQ QGKISVYVAD ALLKKGSMKT GDKLDIKGVG 
301:	QVEVSPNSVQ GYDYEADGNG IVLLPERVIF NKENIGKYDF

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

3.A.1.2.8Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)