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3.A.1.2.8 Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)
Accession Number:	P76142
Protein Name:	LsrB(R)
Length:	340
Molecular Weight:	36685.00
Species:	Escherichia coli [83333]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Periplasm¹
Substrate

RefSeq:	AP_002137.1 NP_416033.1
Entrez Gene ID:	945418
BioCyc:	EcoCyc:YNEA-MONOMER ECOL168927:B1516-MONOMER
KEGG:	ecj:JW1509 eco:b1516
Gene Ontology GO:0042597 C:periplasmic space
References (4) [1] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [3] “Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli.” Xavier K.B.et.al. 15601708 [4] “Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli.” Wang L.et.al. 15743955

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MTLHRFKKIA LLSALGIAAI SMNVQAAERI AFIPKLVGVG FFTSGGNGAQ QAGKELGVDV 
61:	TYDGPTEPSV SGQVQLINNF VNQGYNAIIV SAVSPDGLCP ALKRAMQRGV RVLTWDSDTK 
121:	PECRSYYINQ GTPAQLGGML VDMAARQVNK DKAKVAFFYS SPTVTDQNQW VKEAKAKIAK 
181:	EHPGWEIVTT QFGYNDATKS LQTAEGILKA YSDLDAIIAP DANALPAAAQ AAENLKNDKV 
241:	AIVGFSTPNV MRPYVERGTV KEFGLWDVVQ QGKISVYVAD ALLKKGSMKT GDKLDIKGVG 
301:	QVEVSPNSVQ GYDYEADGNG IVLLPERVIF NKENIGKYDF

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

3.A.1.2.8Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)