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2.A.113.1.1
Ni2+/Co2+ exporter, RcnA/RcnB (Rodrigue et al., 2005; Iwig et al., 2006). RcnB, a small 1 or 2 TMS protein of the DUF3315 or PF11776 family, regulates the activity of RcnA.

Accession Number:P76425
Protein Name:RcnA; aka Nickel/cobalt efflux system
Length:274
Molecular Weight:30419.00
Species:Escherichia coli [83333]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate cobalt(2+), nickel(2+)

Cross database links:

RefSeq: AP_002704.1    NP_416609.1   
Entrez Gene ID: 949078   
Pfam: PF03824   
BioCyc: EcoCyc:G7138-MONOMER    ECOL168927:B2106-MONOMER   
KEGG: ecj:JW2093    eco:b2106   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046872 F:metal ion binding
GO:0006824 P:cobalt ion transport
GO:0015675 P:nickel ion transport
GO:0055085 P:transmembrane transport

References (7)

[1] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli.”  Rodrigue A.et.al.   15805538
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[6] “Nickel homeostasis in Escherichia coli - the rcnR-rcnA efflux pathway and its linkage to NikR function.”  Iwig J.S.et.al.   16956381
[7] “The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis.”  Koch D.et.al.   17120142

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTEFTTLLQQ GNAWFFIPSA ILLGALHGLE PGHSKTMMAA FIIAIKGTIK QAVMLGLAAT 
61:	ISHTAVVWLI AFGGMVISKR FTAQSAEPWL QLISAVIIIS TAFWMFWRTW RGERNWLENM 
121:	HGHDYEHHHH DHEHHHDHGH HHHHEHGEYQ DAHARAHAND IKRRFDGREV TNWQILLFGL 
181:	TGGLIPCPAA ITVLLICIQL KALTLGATLV VSFSIGLALT LVTVGVGAAI SVQQVAKRWS 
241:	GFNTLAKRAP YFSSLLIGLV GVYMGVHGFM GIMR