3.A.1.5.41
Oligopeptide transporter, OppABCDF/MppA/YgiS. MppA is a murein peptide receptor, and YgiS is a bile acid (e.g., cholate, deoxycholate) receptor that may use the Opp system for uptake. YgiS mRNA is degraded by the toxin, MgsR, which is regulated by the antitoxin, MgsA, and this loss of the mRNA protects the cell against bile acid stress (Kwan et al. 2015). oppA translation is activated by MicF through a mechanism of
action involving facilitated access to a translation-enhancing region in
oppA 5'UTR. MicF activation of oppA translation depends on cross-regulation by negative trans-acting effectors, the GcvB sRNA and the RNA chaperone protein Hfq (Carrier et al. 2023).
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| Accession Number: | P77737 |
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| Protein Name: | Oligopeptide transport ATP-binding protein OppF |
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| Length: | 334 |
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| Molecular Weight: | 37198.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Peripheral membrane protein2 |
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| Substrate |
oligopeptide |
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1: MNAVTEGRKV LLEIADLKVH FEIKDGKQWF WQPPKTLKAV DGVTLRLYEG ETLGVVGESG
61: CGKSTFARAI IGLVKATDGH VAWLGKELLG MKPDEWRAVR SDIQMIFQDP LASLNPRMTI
121: GEIIAEPLRT YHPKMSRQEV RERVKAMMLK VGLLPNLINR YPHEFSGGQC QRIGIARALI
181: LEPKLIICDE PVSALDVSIQ AQVVNLLQQL QREMGLSLIF IAHDLAVVKH ISDRVLVMYL
241: GHAVELGTYD EVYHNPLHPY TRALMSAVPI PDPDLEKNKT IQLLEGELPS PINPPSGCVF
301: RTRCPIAGPE CAKTRPVLEG SFRHSVSCLK VDPL