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3.C.1.1.1
Na+-transporting tetrahydromethanopterin S-methyltransferase (NMM), MtrABCDEFGH (Harms et al. 1995).  MtrA shows a short region of sequence similarity with MtrF; MtrB shows a shortregion of sezquence similarity with MtrG (all in their C-terminal TMSs). However, MtrC, D, E and H do not show noticable sequence similarity with other members of this system.

Accession Number:P80186
Protein Name:MtrE
Length:295
Molecular Weight:31232.00
Species:Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133) [79929]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate sodium(1+)

Cross database links:

Pfam: PF04206   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0012506 C:vesicle membrane
GO:0030269 F:tetrahydromethanopterin S-methyltransferase...
GO:0015948 P:methanogenesis
GO:0006730 P:one-carbon metabolic process
GO:0006814 P:sodium ion transport

References (3)

[1] “The energy conserving N5-methyltetrahydromethanopterin:coenzyme M methyltransferase complex from Methanobacterium thermoautotrophicum is composed of eight different subunits.”  Harms U.et.al.   7737157
[2] “Cloning, sequencing and immunological characterization of the corrinoid-containing subunit of the N5-methyltetrahydromethanopterin: coenzyme-M methyltransferase from Methanobacterium thermoautotrophicum.”  Stupperich E.et.al.   8223548
[3] “Purification and properties of N5-methyltetrahydromethanopterin:coenzyme M methyltransferase from Methanobacterium thermoautotrophicum.”  Gaertner P.et.al.   8477726

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MDPMITGLGV VALMGAAATI AGAAEDLESD VGSQSNPNSQ VQLAPQMGHL HRIINKAVSG 
61:	EPVAYGTWCG IAGSVAFVLM NSMQLPVIMA IAIGAVIAAM VHTTYAVTSH MGRIVSQSQF 
121:	NQPLFMDMLV QHLGPIAGHG FIVTFCTVGL SYLMTLPIPG FAHPFPLPLL AVLWGITIGA 
181:	IGSSTGDVHY GAEREYQQYP FGGGIPVAIH GDITTKAELG ARNSMDVVHF CAKYGGPLTG 
241:	FAFGAIVFLS FWNTIVFGIT GGIISGLIIV LLLIILNNRL EVFARNRYGP YKEEE