2.A.5.1.15
Zinc transporter, Zrt1 of 468 aas and 7 TMSs. Receives Zn2+ from the secreted, extracellular zincophore protein, Pra1 for uptake of the metal. The binding site in Pra1 is in the C-terminal region of this 299 aa protein (Łoboda and Rowińska-Żyrek 2017). Pra1 is a cell surface protein with a single N-terminal TMS involved in the
host-parasite interaction during candidal infection. With MP65, it
represents a major component of the biofilm matrix. It sequesters zinc from
host tissues and mediates leukocyte adhesion and migration (Citiulo et al. 2012).
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| Accession Number: | P87020 |
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| Protein Name: | pH-regulated antigen PRA1 |
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| Length: | 299 |
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| Molecular Weight: | 33159.00 |
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| Species: | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [237561] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MNYLLFCLFF AFSVAAPVTV TRFVDASPTG YDWRADWVKG FPIDSSCNAT QYNQLSTGLQ
61: EAQLLAEHAR DHTLRFGSKS PFFRKYFGNE TASAEVVGHF DNVVGADKSS ILFLCDDLDD
121: KCKNDGWAGY WRGSNHSDQT IICDLSFVTR RYLTQLCSSG YTVSKSKTNI FWAGDLLHRF
181: WHLKSIGQLV IEHYADTYEE VLELAQENST YAVRNSNSLI YYALDVYAYD VTIPGEGCNG
241: DGTSYKKSDF SSFEDSDSGS DSGASSTASS SHQHTDSNPS ATTDANSHCH THADGEVHC