3.A.7.12.1
The Cag pathogenicity island (PAI) proteins (Kutter et al., 2008). CagD (Cag24) is essential for CagA translocation and maximal induction of interleukin-8 secretion (Cendron et al., 2009). It is required for a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Its molecular properties are described in a review by Fischer (2011). Cag16 (CagM) (of unknown function and not dermonstrably homologous to proteins of type IV secretion systems in other bacteria) has 3-4 TMSs and is essential for CagA export. It may therefore be a core protein of the Cag complex (Ling et al. 2013).
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| Accession Number: | P97245 |
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| Protein Name: | Cag12 |
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| Length: | 280 |
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| Molecular Weight: | 32374.00 |
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| Species: | Helicobacter pylori (Campylobacter pylori) [210] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Lipid-anchor2 |
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| Substrate |
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| DIP: |
DIP-3589N
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| RefSeq: |
NP_207328.1
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| Entrez Gene ID: |
898927
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| KEGG: |
hpy:HP0532
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[1] “cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.” Censini S. et.al. 8962108
[2] “Analyses of the cag pathogenicity island of Helicobacter pylori.” Akopyants N.S. et.al. 9593295
[3] “The complete genome sequence of the gastric pathogen Helicobacter pylori.” Tomb J.-F. et.al. 9252185
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1: MKLRASVLIG ATILCLILSA CSNYAKKVVK QKNHVYTPVY NELIEKYSEI PLNDKLKDTP
61: FMVQVKLPNY KDYLLDNKQV VLTFKLVHHS KKITLIGDAN KILQYKNYFQ ANGARSDIDF
121: YLQPTLNQKG VVMIASNYND NPNSKEKPQT FDVLQGSQPM LGANTKNLHG YDVSGANNKQ
181: VINEVAREKA QLEKINQYYK TLLQDKEQEY TTRKNNQREI LETLSNRAGY QMRQNVISSE
241: IFKNGNLNMQ AKEEEVREKL QEERENEYLR NQIRSLLSGK