9.B.282.1.1 Proteins of the iniBAC operon all give rise to multidrug resistance when mutated. They may function with the MFS drug efflux pump, EfpA (TC# 2.A.1.3.78). See family description for the evidence that ImiABC is involved in drug resistance (Colangeli et al. 2007). ImiA and ImiC have N-terminal regions that are homologous to each other. IniB is rich in glycines and shows apparent similarity to members of families 9.B.96, 1.B.89, 1.B.94 and 1.B.95, all of which may belong to the PE/PPE superfamily and are glycine-rich. The apparent similarity may be an artifactual due the presence of redundant sequences of similar limited amino acid compositions.
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Accession Number: | P9WJ95 |
Protein Name: | Isoniazid-induced protein IniC |
Length: | 493 |
Molecular Weight: | 53019.00 |
Species: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332] |
Number of TMSs: | 2 |
Substrate |
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1: MSTSDRVRAI LHATIQAYRG APAYRQRGDV FCQLDRIGAR LAEPLRIALA GTLKAGKSTL
61: VNALVGDDIA PTDATEATRI VTWFRHGPTP RVTANHRGGR RANVPITRRG GLSFDLRRIN
121: PAELIDLEVE WPAEELIDAT IVDTPGTSSL ACDASERTLR LLVPADGVPR VDAVVFLLRT
181: LNAADVALLK QIGGLVGGSV GALGIIGVAS RADEIGAGRI DAMLSANDVA KRFTRELNQM
241: GICQAVVPVS GLLALTARTL RQTEFIALRK LAGAERTELN RALLSVDRFV RRDSPLPVDA
301: GIRAQLLERF GMFGIRMSIA VLAAGVTDST GLAAELLERS GLVALRNVID QQFAQRSDML
361: KAHTALVSLR RFVQTHPVPA TPYVIADIDP LLADTHAFEE LRMLSLLPSR ATTLNDDEIA
421: SLRRIIGGSG TSAAARLGLD PANSREAPRA ALAAAQHWRR RAAHPLNDPF TTRACRAAVR
481: SAEAMVAEFS ARR