9.B.282.1.1 Proteins of the iniBAC operon all give rise to multidrug resistance when mutated. They may function with the MFS drug efflux pump, EfpA (TC# 2.A.1.3.78). See family description for the evidence that ImiABC is involved in drug resistance (Colangeli et al. 2007). ImiA and ImiC have N-terminal regions that are homologous to each other. IniB is rich in glycines and shows apparent similarity to members of families 9.B.96, 1.B.89, 1.B.94 and 1.B.95, all of which may belong to the PE/PPE superfamily and are glycine-rich. The apparent similarity may be an artifactual due the presence of redundant sequences of similar limited amino acid compositions.
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Accession Number: | P9WJ97 |
Protein Name: | Isoniazid-induced protein IniB |
Length: | 479 |
Molecular Weight: | 43921.00 |
Species: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332] |
Number of TMSs: | 4 |
Substrate |
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1: MTSLIDYILS LFRSEDAARS FVAAPGRAMT SAGLIDIAPH QISSVAANVV PGLNLGAGDP
61: MSGLRQAVAA RHGFAQDVAN VGFAGDAGAG VASVITTDVG AGLASGLGAG FLGQGGLALA
121: ASSGGFGGQV GLAAQVGLGF TAVIEAEVGA QVGAGLGIGT GLGAQAGMGF GGGVGLGLGG
181: QAGGVIGGSA AGAIGAGVGG RLGGNGQIGV AGQGAVGAGV GAGVGGQAGI ASQIGVSAGG
241: GLGGVGNVSG LTGVSSNAVL ASNASGQAGL IASEGAALNG AAMPHLSGPL AGVGVGGQAG
301: AAGGAGLGFG AVGHPTPQPA ALGAAGVVAK TEAAAGVVGG VGGATAAGVG GAHGDILGHE
361: GAALGSVDTV NAGVTPVEHG LVLPSGPLIH GGTGGYGGMN PPVTDAPAPQ VPARAQPMTT
421: AAEHTPAVTQ PQHTPVEPPV HDKPPSHSVF DVGHEPPVTH TPPAPIELPS YGLFGLPGF