9.B.282.1.1
Proteins of the iniBAC operon all give rise to multidrug resistance when mutated. They may function with the MFS drug efflux pump, EfpA (TC# 2.A.1.3.78). See family description for the evidence that ImiABC is involved in drug resistance (Colangeli et al. 2007). ImiA and ImiC have N-terminal regions that are homologous to each other. IniB is rich in glycines and shows apparent similarity to members of families 9.B.96, 1.B.89, 1.B.94 and 1.B.95, all of which may belong to the PE/PPE superfamily and are glycine-rich. The apparent similarity may be an artifactual due the presence of redundant sequences of similar limited amino acid compositions.
|
| Accession Number: | P9WJ99 |
|---|
| Protein Name: | Isoniazid-induced protein IniA |
|---|
| Length: | 640 |
|---|
| Molecular Weight: | 70083.00 |
|---|
| Species: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332] |
|---|
| Number of TMSs: | 2 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MVPAGLCAYR DLRRKRARKW GDTVTQPDDP RRVGVIVELI DHTIAIAKLN ERGDLVQRLT
61: RARQRITDPQ VRVVIAGLLK QGKSQLLNSL LNLPAARVGD DEATVVITVV SYSAQPSARL
121: VLAAGPDGTT AAVDIPVDDI STDVRRAPHA GGREVLRVEV GAPSPLLRGG LAFIDTPGVG
181: GLGQPHLSAT LGLLPEADAV LVVSDTSQEF TEPEMWFVRQ AHQICPVGAV VATKTDLYPR
241: WREIVNANAA HLQRARVPMP IIAVSSLLRS HAVTLNDKEL NEESNFPAIV KFLSEQVLSR
301: ATERVRAGVL GEIRSATEQL AVSLGSELSV VNDPNLRDRL ASDLERRKRE AQQAVQQTAL
361: WQQVLGDGFN DLTADVDHDL RTRFRTVTED AERQIDSCDP TAHWAEIGND VENAIATAVG
421: DNFVWAYQRS EALADDVARS FADAGLDSVL SAELSPHVMG TDFGRLKALG RMESKPLRRG
481: HKMIIGMRGS YGGVVMIGML SSVVGLGLFN PLSVGAGLIL GRMAYKEDKQ NRLLRVRSEA
541: KANVRRFVDD ISFVVSKQSR DRLKMIQRLL RDHYREIAEE ITRSLTESLQ ATIAAAQVAE
601: TERDNRIREL QRQLGILSQV NDNLAGLEPT LTPRASLGRA